Polymerization of actin filaments against membranes produces force for numerous cellular
processes, such as migration, morphogenesis, endocytosis, phagocytosis and organelle …

Arp2/3 complex is an actin filament nucleation and branching machinery conserved in all
eukaryotes from yeast to human. Arp2/3 complex branched networks generate pushing …

Membrane protrusions at the leading edge of cells, known as lamellipodia, drive cell
migration in many normal and pathological situations. Lamellipodial protrusion is powered …

Summary Actin-related protein 2/3 (Arp2/3) complex is a seven-subunit assembly that
nucleates branched actin filaments. Small molecule inhibitors CK-666 and CK-869 bind to …

Endocytosis includes a number of processes by which cells internalize segments of their
plasma membrane, enclosing a wide variety of material from outside the cell. Endocytosis …

Endocytosis, the process whereby the plasma membrane invaginates to form vesicles, is
essential for bringing many substances into the cell and for membrane turnover. The …

Arp2/3 complex nucleates branched actin filaments that provide pushing forces to drive
cellular processes such as lamellipodial protrusion and endocytosis. Arp2/3 complex is …

Clathrin-mediated endocytosis is an essential cellular function in all eukaryotes that is driven
by a self-assembled macromolecular machine of over 50 different proteins in tens to …

Microglia are the tissue-resident immune cells of the central nervous system, where they
constitute the first line of defense against any pathogens or injury. Microglia are highly motile …

Endoplasmic reticulum (ER) membrane contact sites (MCSs) mark positions where
endosomes undergo fission for cargo sorting. To define the role of ER at this unique MCS …