Radiometals comprise many useful radioactive isotopes of various metallic elements. When
properly harnessed, these have valuable emission properties that can be used for …

Medical imaging, which empowers the detection of physiological and pathological
processes within living subjects, has a vital role in both preclinical and clinical diagnostics …

Theranostics for in vivo cancer diagnosis and treatment generally requires well-designed
nanoscale platforms with multiple integrated functionalities. In this study, we uncover that …

Checkpoint-blocking antibodies like those targeting the PD-1/PD-L1 pathway have
revolutionized oncology. We developed radiotracers based on therapeutic checkpoint …

IL15, a potent stimulant of CD8+ T cells and natural killer (NK) cells, is a promising cancer
immunotherapeutic. ALT-803 is a complex of an IL15 superagonist mutant and a dimeric …

Herein we demonstrate that nanographene can be specifically directed to the tumor
neovasculature in vivo through targeting of CD105 (ie, endoglin), a vascular marker for …

At their margins, tumors often contain neutrophils, dendritic cells, and activated
macrophages, which express class II MHC and CD11b products. The interplay between …

Over the last twenty-five years 1, 4, 7, 10-tetraazacyclododecane-1, 4, 7, 10-tetraacetic acid
(DOTA) has made a significant impact on the field of diagnostic imaging. DOTA is not the …

Antibodies have long been recognised as potent vectors for carrying diagnostic medical
radionuclides, contrast agents and optical probes to diseased tissue for imaging. The area of …

Therapeutic radiopharmaceuticals have been researched extensively in the last decade as
a result of the growing research interest in personalized medicine to improve diagnostic …