Membranous nephropathy: new pathogenic mechanisms and their clinical implications
E Hoxha, L Reinhard, RAK Stahl - Nature Reviews Nephrology, 2022 - nature.com
Membranous nephropathy (MN) is characterized histomorphologically by the presence of
immune deposits in the subepithelial space of the glomerular filtration barrier; its clinical …
immune deposits in the subepithelial space of the glomerular filtration barrier; its clinical …
New 'antigens' in membranous nephropathy
S Sethi - Journal of the American Society of Nephrology, 2021 - journals.lww.com
Membranous nephropathy (MN) occurs due to deposition of immune complexes along the
subepithelial region of glomerular basement membrane. Two previously identified target …
subepithelial region of glomerular basement membrane. Two previously identified target …
Complexities of the glomerular basement membrane
The glomerular basement membrane (GBM) is a key component of the glomerular capillary
wall and is essential for kidney filtration. The major components of the GBM include …
wall and is essential for kidney filtration. The major components of the GBM include …
[HTML][HTML] Neural epidermal growth factor-like 1 protein (NELL-1) associated membranous nephropathy
S Sethi, H Debiec, B Madden, MC Charlesworth… - Kidney international, 2020 - Elsevier
Membranous nephropathy is characterized by deposition of immune complexes along the
glomerular basement membrane. PLA2R and THSD7A are target antigens in 70% and 1-5 …
glomerular basement membrane. PLA2R and THSD7A are target antigens in 70% and 1-5 …
Protocadherin 7–associated membranous nephropathy
Background Membranous nephropathy (MN) results from deposition of antigen-antibody
complexes along the glomerular basement membrane (GBM). PLA2R, THSD7A, NELL1 …
complexes along the glomerular basement membrane (GBM). PLA2R, THSD7A, NELL1 …
[HTML][HTML] Semaphorin 3B–associated membranous nephropathy is a distinct type of disease predominantly present in pediatric patients
S Sethi, H Debiec, B Madden, M Vivarelli… - Kidney international, 2020 - Elsevier
Membranous nephropathy results from subepithelial antigen-antibody complex deposition
along the glomerular basement membrane. Although PLA2R, THSD7A, and NELL-1 …
along the glomerular basement membrane. Although PLA2R, THSD7A, and NELL-1 …
Exostosin 1/exostosin 2–associated membranous nephropathy
S Sethi, BJ Madden, H Debiec… - Journal of the …, 2019 - journals.lww.com
Background In membranous nephropathy (MN), which is characterized by deposition of
immune complexes along the glomerular basement membrane (GBM), phospholipase A2 …
immune complexes along the glomerular basement membrane (GBM), phospholipase A2 …
Altered glycosylation of IgG4 promotes lectin complement pathway activation in anti-PLA2R1–associated membranous nephropathy
G Haddad, JM Lorenzen, H Ma… - The Journal of …, 2021 - Am Soc Clin Investig
Primary membranous nephropathy (pMN) is a leading cause of nephrotic syndrome in
adults. In most cases, this autoimmune kidney disease is associated with autoantibodies …
adults. In most cases, this autoimmune kidney disease is associated with autoantibodies …
Identification of serum metabolites associating with chronic kidney disease progression and anti-fibrotic effect of 5-methoxytryptophan
DQ Chen, G Cao, H Chen, CP Argyopoulos… - Nature …, 2019 - nature.com
Early detection and accurate monitoring of chronic kidney disease (CKD) could improve
care and retard progression to end-stage renal disease. Here, using untargeted …
care and retard progression to end-stage renal disease. Here, using untargeted …
Membranous nephropathy
P Ronco, L Beck, H Debiec, FC Fervenza… - Nature reviews Disease …, 2021 - nature.com
Membranous nephropathy (MN) is a glomerular disease that can occur at all ages. In adults,
it is the most frequent cause of nephrotic syndrome. In~ 80% of patients, there is no …
it is the most frequent cause of nephrotic syndrome. In~ 80% of patients, there is no …