Repurposing small-molecule drugs for modulating toxic protein aggregates in neurodegenerative diseases

W Liu, G Wang, Z Wang, G Wang, J Huang, B Liu - Drug discovery today, 2022 - Elsevier
Neurodegenerative diseases (NDs) are often age-related disorders that can cause dementia
in people, usually over 65 years old, are still lacking effective therapies. Some NDs have …

Early detection of cognitive decline using machine learning algorithm and cognitive ability test

A Revathi, R Kaladevi, K Ramana… - Security and …, 2022 - Wiley Online Library
Elderly people are the assets of the country and the government can ensure their peaceful
and healthier life. Life expectancy of individuals has expanded with technological …

Regular proton pump inhibitor use and incident dementia: population-based cohort study

P Zhang, Z Li, P Chen, A Zhang, Y Zeng, X Zhang… - BMC medicine, 2022 - Springer
Background To examine the association between regular use of proton pump inhibitors and
the risk of incident dementia, including dementia subtypes, and whether the association …

Benzodiazepine use and the risk of dementia

G Joyce, P Ferido, J Thunell, B Tysinger… - … Research & Clinical …, 2022 - Wiley Online Library
Abstract Introduction Benzodiazepines (BZDs) are commonly prescribed for anxiety and
agitations, which are early symptoms of Alzheimer's disease and related dementias (ADRD) …

The Janus-like association between proton pump inhibitors and dementia

A Papazoglou, MI Arshaad, C Henseler… - Current Alzheimer …, 2021 - benthamdirect.com
Early pharmacoepidemiological studies suggested that Proton Pump Inhibitors (PPIs) might
increase the risk of Alzheimer's Disease (AD) and non-AD related dementias. These findings …

CLADSI: Deep Continual Learning for Alzheimer's Disease Stage identification using accelerometer data

S Bringas, R Duque, C Lage… - IEEE Journal of …, 2024 - ieeexplore.ieee.org
Alzheimer's disease (AD) is a neurodegenerative disorder that can cause a significant
impairment in physical and cognitive functions. Gait disturbances are also reported as a …

Association between colchicine use and the risk of dementia among patients with gout: A nationwide retrospective cohort study

PY Chen, CC Tseng, YT Lee, HT Yip… - International Journal …, 2024 - Wiley Online Library
Background Recent findings suggest a link between gout and the development of dementia.
Early treatment with colchicine is recommended as a first‐line therapy for gout flares. Animal …

Preventing Alzheimer's disease within reach by 2025: Targeted‐risk‐AD‐prevention (TRAP) strategy

F Vitali, GL Branigan, RD Brinton - Alzheimer's & Dementia …, 2021 - Wiley Online Library
Introduction Alzheimer's disease (AD) is a progressive neurodegenerative disease that
currently affects 6.2 million people in the United States and is projected to impact 152 million …

[HTML][HTML] An assessment of the mediating role of hypertension in the effect of long-term air pollution exposure on dementia

TE Libby, SD Ilango, CS Leary… - Environmental …, 2024 - journals.lww.com
Background: Growing evidence links air pollution exposure to the risk of dementia. We
hypothesized that hypertension may partially mediate this effect. Methods: We previously …

Re‐remembering the influence of randomized β‐carotene on cognitive decline

RE Kopec, DI Chasman, OI Okereke… - Alzheimer's & …, 2023 - Wiley Online Library
The wave of individuals impacted by dementia continues to rise rapidly as worldwide
lifespan increases. Dietary strategies to slow cognitive decline and prolong time to clinical …