Repurposing small-molecule drugs for modulating toxic protein aggregates in neurodegenerative diseases
W Liu, G Wang, Z Wang, G Wang, J Huang, B Liu - Drug discovery today, 2022 - Elsevier
Neurodegenerative diseases (NDs) are often age-related disorders that can cause dementia
in people, usually over 65 years old, are still lacking effective therapies. Some NDs have …
in people, usually over 65 years old, are still lacking effective therapies. Some NDs have …
Early detection of cognitive decline using machine learning algorithm and cognitive ability test
Elderly people are the assets of the country and the government can ensure their peaceful
and healthier life. Life expectancy of individuals has expanded with technological …
and healthier life. Life expectancy of individuals has expanded with technological …
Regular proton pump inhibitor use and incident dementia: population-based cohort study
Background To examine the association between regular use of proton pump inhibitors and
the risk of incident dementia, including dementia subtypes, and whether the association …
the risk of incident dementia, including dementia subtypes, and whether the association …
Benzodiazepine use and the risk of dementia
Abstract Introduction Benzodiazepines (BZDs) are commonly prescribed for anxiety and
agitations, which are early symptoms of Alzheimer's disease and related dementias (ADRD) …
agitations, which are early symptoms of Alzheimer's disease and related dementias (ADRD) …
The Janus-like association between proton pump inhibitors and dementia
A Papazoglou, MI Arshaad, C Henseler… - Current Alzheimer …, 2021 - benthamdirect.com
Early pharmacoepidemiological studies suggested that Proton Pump Inhibitors (PPIs) might
increase the risk of Alzheimer's Disease (AD) and non-AD related dementias. These findings …
increase the risk of Alzheimer's Disease (AD) and non-AD related dementias. These findings …
CLADSI: Deep Continual Learning for Alzheimer's Disease Stage identification using accelerometer data
S Bringas, R Duque, C Lage… - IEEE Journal of …, 2024 - ieeexplore.ieee.org
Alzheimer's disease (AD) is a neurodegenerative disorder that can cause a significant
impairment in physical and cognitive functions. Gait disturbances are also reported as a …
impairment in physical and cognitive functions. Gait disturbances are also reported as a …
Association between colchicine use and the risk of dementia among patients with gout: A nationwide retrospective cohort study
Background Recent findings suggest a link between gout and the development of dementia.
Early treatment with colchicine is recommended as a first‐line therapy for gout flares. Animal …
Early treatment with colchicine is recommended as a first‐line therapy for gout flares. Animal …
Preventing Alzheimer's disease within reach by 2025: Targeted‐risk‐AD‐prevention (TRAP) strategy
Introduction Alzheimer's disease (AD) is a progressive neurodegenerative disease that
currently affects 6.2 million people in the United States and is projected to impact 152 million …
currently affects 6.2 million people in the United States and is projected to impact 152 million …
[HTML][HTML] An assessment of the mediating role of hypertension in the effect of long-term air pollution exposure on dementia
TE Libby, SD Ilango, CS Leary… - Environmental …, 2024 - journals.lww.com
Background: Growing evidence links air pollution exposure to the risk of dementia. We
hypothesized that hypertension may partially mediate this effect. Methods: We previously …
hypothesized that hypertension may partially mediate this effect. Methods: We previously …
Re‐remembering the influence of randomized β‐carotene on cognitive decline
RE Kopec, DI Chasman, OI Okereke… - Alzheimer's & …, 2023 - Wiley Online Library
The wave of individuals impacted by dementia continues to rise rapidly as worldwide
lifespan increases. Dietary strategies to slow cognitive decline and prolong time to clinical …
lifespan increases. Dietary strategies to slow cognitive decline and prolong time to clinical …