The epithelial and mesenchymal cells involved in early embryonic facial development are
guided by complex regulatory mechanisms. Any factor perturbing the growth, approach and …

Notch signaling regulates a vast array of crucial developmental processes. It is therefore not
surprising that mutations in genes encoding Notch receptors or ligands lead to a variety of …

Background Epigenetic data could help identify risk factors for orofacial clefts, either by
revealing a causal role for epigenetic mechanisms in causing clefts or by capturing …

Understanding the developmental etiology of autistic spectrum disorders, attention
deficit/hyperactivity disorder and schizophrenia remains a major challenge for establishing …

The fusion of two distinct prominences into one continuous structure is common during
development and typically requires integration of two epithelia and subsequent removal of …

The fibroblast growth factors (FGFs) play a critical role during palatogenesis by mediating a
variety of cellular responses. Extensive epidemiological and genetic studies over several …

Background Although various genes and genomic regions were described as of
susceptibility for nonsyndromic oral clefts (NOC), recent reports have demonstrated …

Cleft lip and cleft palate (CL/P) are among the most common congenital malformations in
neonates and have syndromic or nonsyndromic forms. Nonsyndromic forms of malformation …

Objective This study assesses the degree of root curvature in patients with non-syndromic
cleft lip and/or palate (NSCL/P). Design Retrospective. Case-control study. Setting Root …

Objective Normal development of the embryonic orofacial region requires precise
spatiotemporal coordination between numerous genes. MicroRNAs represent small, single …