Epstein-Barr virus (EBV) is a model of herpesvirus latency and epigenetic changes. The
virus preferentially infects human B-lymphocytes (and also other cell types) but does not turn …

An important reason for preferring mammalian cells for heterologous gene expression is
their ability to make authentic proteins containing post‐translational modifications similar to …

Epstein-Barr virus (EBV) productive DNA replication occurs at discrete sites, called
replication compartments, in nuclei. In this study we performed comprehensive analyses of …

This study describes the development of a transient expression system for CHO cells based
on autonomous replication and retention of transfected plasmid DNA. A transient expression …

In order to analyze epigenetic factors involved in the regulation of DNA replication in higher
eukaryotic cells, minimal systems have to be established. We have recently constructed a …

Background EBV lytic cycle activators, such as phorbol esters, anti-immunoglobulin,
transforming growth factor β (TGFβ), sodium butyrate, induce apoptosis in EBV-negative but …

Publisher Summary This chapter discusses the nature and function of eukaryotic viral
genome-linked proteins (VPgs) and outlines some of the remarkable features of these …

Plasmids containing the origin of replication, oriP, of the Epstein-Barr virus (EBV) and EBV
nuclear antigen-1 genes replicate extrachromosomally in primate cells. However, these …

Background Poly (ADP-ribosylation) is a post-translational modification of nuclear proteins
involved in several cellular events as well as in processes that characterize the infective …

Kaposi's sarcoma-associated herpesvirus (KSHV) is thought to be an oncogenic member of
the γ-herpesvirus subfamily. The virus usually establishes latency upon infection as a default …