Through the looking glass: chiral recognition of substrates and products at the active sites of racemases and epimerases
SL Bearne - Chemistry–A European Journal, 2020 - Wiley Online Library
Unlike most enzymes, which exhibit stereospecific substrate binding, racemases and
epimerases bind and catalyze the reversible interconversion of enantiomeric and epimeric …
epimerases bind and catalyze the reversible interconversion of enantiomeric and epimeric …
Glutamate Racemase Is the Primary Target of β-Chloro-d-Alanine in Mycobacterium tuberculosis
GA Prosser, A Rodenburg, H Khoury… - Antimicrobial agents …, 2016 - Am Soc Microbiol
The increasing global prevalence of drug resistance among many leading human
pathogens necessitates both the development of antibiotics with novel mechanisms of action …
pathogens necessitates both the development of antibiotics with novel mechanisms of action …
Biochemical Characterization of Glutamate Racemase—A New Candidate Drug Target against Burkholderia cenocepacia Infections
The greatest obstacle for the treatment of cystic fibrosis patients infected with the
Burkholderia species is their intrinsic antibiotic resistance. For this reason, there is a need to …
Burkholderia species is their intrinsic antibiotic resistance. For this reason, there is a need to …
Application of circular dichroism-based assays to racemases and epimerases: Recognition and catalysis of reactions of chiral substrates by mandelate racemase
SL Bearne, JA Hayden - Methods in Enzymology, 2023 - Elsevier
Racemases and epimerases have attracted much interest because of their astonishing
ability to catalyze the rapid α-deprotonation of carbon acid substrates with high p K a values …
ability to catalyze the rapid α-deprotonation of carbon acid substrates with high p K a values …
Inhibition of glutamate racemase by substrate–product analogues
Abstract d-Glutamate is an essential biosynthetic building block of the peptidoglycans that
encapsulate the bacterial cell wall. Glutamate racemase catalyzes the reversible formation …
encapsulate the bacterial cell wall. Glutamate racemase catalyzes the reversible formation …
Recombinant expression, purification and characterisation of the native glutamate racemase from Lactobacillus plantarum NC8
N Böhmer, A Dautel, T Eisele, L Fischer - Protein expression and …, 2013 - Elsevier
Glutamic acid racemases (MurI, EC 5.1. 1.3) catalyse the racemisation of l-and d-glutamic
acid. MurIs are essential enzymes for bacterial cell wall synthesis, which requires d-glutamic …
acid. MurIs are essential enzymes for bacterial cell wall synthesis, which requires d-glutamic …
Applanatines A–E from the culture broth of Ganoderma applanatum
K Fushimi, M Horikawa, K Suzuki, A Sekiya, S Kanno… - Tetrahedron, 2010 - Elsevier
Five novel compounds, applanatines A–E (1–5), and a known one (6) were isolated from the
culture broth of Ganoderma applanatum. Their structures including the relative …
culture broth of Ganoderma applanatum. Their structures including the relative …
Design and evaluation of substrate–product analog inhibitors for racemases and epimerases utilizing a 1, 1-proton transfer mechanism
SL Bearne - Methods in Enzymology, 2023 - Elsevier
Racemases and epimerases catalyze the inversion of stereochemistry at asymmetric carbon
atoms to generate stereoisomers that often play important roles in normal and pathological …
atoms to generate stereoisomers that often play important roles in normal and pathological …
Significance of Glutamate Racemase for the Viability and Cell Wall Integrity of Streptococcus iniae
Streptococcus iniae is a pathogenic and zoonotic bacterium responsible for human diseases
and mortality of many fish species. Recently, this bacterium has demonstrated an increasing …
and mortality of many fish species. Recently, this bacterium has demonstrated an increasing …
Changes in quaternary structure cause a kinetic asymmetry of glutamate racemase‐catalyzed homocysteic acid racemization
Glutamate racemases (GR) catalyze the racemization of d‐and l‐glutamate and are targets
for the development of antibiotics. We demonstrate that GR from the periodontal pathogen …
for the development of antibiotics. We demonstrate that GR from the periodontal pathogen …