Over the last 100–120 years, due to the ever-increasing importance of fluorine-containing
compounds in modern technology and daily life, the explosive development of the …

The electronic properties and relatively small size of fluorine endow it with considerable
versatility as a bioisostere and it has found application as a substitute for lone pairs of …

The applications of fluorine in drug design continue to expand, facilitated by an improved
understanding of its effects on physicochemical properties and the development of synthetic …

The activation and functionalization of C–F bonds under mild conditions can serve as an
important tool for organic syntheses including the modification of pharmaceuticals and …

Plant-parasitic nematodes have caused huge economic losses to agriculture worldwide and
seriously threaten the sustainable development of modern agriculture. Chemical …

Direct CAr–F arylation is effective and sustainable for synthesis of polyfluorobiaryls with
different degrees of fluorination, which are important motifs in medical and material …

The design of bioisosteres represents a creative and productive approach to improve a
molecule, including by enhancing potency, addressing pharmacokinetic challenges …

We report a trifluoromethylarene reductive coupling method that dramatically expands the
scope of difluorobenzylic substructures accessible via C–F bond functionalization. Catalytic …

The enzymatic generation of carbon–halogen bonds is a powerful strategy used by both
nature and synthetic chemists to tune the bioactivity, bioavailability and reactivity of …

Fluorinated organoboranes serve as versatile synthetic precursors for the preparation of
value‐added fluorinated organic compounds. Recent progress has been mainly focused on …