Network-based machine learning approach to predict immunotherapy response in cancer patients

JH Kong, D Ha, J Lee, I Kim, M Park, SH Im… - Nature …, 2022 - nature.com
Immune checkpoint inhibitors (ICIs) have substantially improved the survival of cancer
patients over the past several years. However, only a minority of patients respond to ICI …

Network-based machine learning in colorectal and bladder organoid models predicts anti-cancer drug efficacy in patients

JH Kong, H Lee, D Kim, SK Han, D Ha, K Shin… - Nature …, 2020 - nature.com
Cancer patient classification using predictive biomarkers for anti-cancer drug responses is
essential for improving therapeutic outcomes. However, current machine-learning-based …

COMPUTATIONAL AND BIOCHEMICAL APPROACHES FOR THE PREDICTION AND CHARACTERIZATION OF DNA REPAIR SYNERGY IN CANCERS

JM Gast - 2021 - hammer.purdue.edu
This thesis Cancer is the second leading cause of death in the modern world, only trailing
congestive heart disease. Many factors contribute to the mortality rate, including the diversity …

Mathematical tools for analysis of genome function, linkage disequilibrium structure and disease gene prediction

N Vergara Lope Gracia - 2021 - eprints.soton.ac.uk
Next-generation sequencing (NGS) help to identify disease-causing genes underlying any
given monogenic or complex disease. Concurrently, mathematical tools and statistical …