Generic nature of the condensed states of proteins

M Fuxreiter, M Vendruscolo - Nature cell biology, 2021 - nature.com
Proteins undergoing liquid–liquid phase separation are being discovered at an increasing
rate. Since at the high concentrations present in the cell most proteins would be expected to …

The structure and dynamics of higher-order assemblies: amyloids, signalosomes, and granules

H Wu, M Fuxreiter - Cell, 2016 - cell.com
We here attempt to achieve an integrated understanding of the structure and dynamics of a
number of higher-order assemblies, including amyloids, various kinds of signalosomes, and …

Spliceosome structure and function

CL Will, R Lührmann - Cold Spring Harbor perspectives …, 2011 - cshperspectives.cshlp.org
Pre-mRNA splicing is catalyzed by the spliceosome, a multimegadalton ribonucleoprotein
(RNP) complex comprised of five snRNPs and numerous proteins. Intricate RNA-RNA and …

RNA-binding proteins: modular design for efficient function

BM Lunde, C Moore, G Varani - Nature reviews Molecular cell biology, 2007 - nature.com
Many RNA-binding proteins have modular structures and are composed of multiple repeats
of just a few basic domains that are arranged in various ways to satisfy their diverse …

The RNA recognition motif, a plastic RNA‐binding platform to regulate post‐transcriptional gene expression

C Maris, C Dominguez, FHT Allain - The FEBS journal, 2005 - Wiley Online Library
The RNA recognition motif (RRM), also known as RNA‐binding domain (RBD) or
ribonucleoprotein domain (RNP) is one of the most abundant protein domains in eukaryotes …

Fuzzy complexes: polymorphism and structural disorder in protein–protein interactions

P Tompa, M Fuxreiter - Trends in biochemical sciences, 2008 - cell.com
The notion that all protein functions are determined through macromolecular interactions is
the driving force behind current efforts that aim to solve the structures of all cellular …

RNA recognition motifs: boring? Not quite

A Cléry, M Blatter, FHT Allain - Current opinion in structural biology, 2008 - Elsevier
The RNA recognition motif (RRM) is one of the most abundant protein domains in
eukaryotes. While the structure of this domain is well characterized by the packing of two α …

[HTML][HTML] Fuzzy complexes: Specific binding without complete folding

R Sharma, Z Raduly, M Miskei, M Fuxreiter - FEBS letters, 2015 - Elsevier
Specific molecular recognition is assumed to require a well-defined set of contacts and
devoid of conformational and interaction ambiguities. Growing experimental evidence …

Protein factors in pre-mRNA 3′-end processing

CR Mandel, Y Bai, L Tong - Cellular and Molecular Life Sciences, 2008 - Springer
Most eukaryotic mRNA precursors (premRNAs) must undergo extensive processing,
including cleavage and polyadenylation at the 3′-end. Processing at the 3′-end is …

[图书][B] Structure and function of intrinsically disordered proteins

P Tompa, A Fersht - 2009 - taylorfrancis.com
The existence and functioning of intrinsically disordered proteins (IDPs) challenge the
classical structure-function paradigm that equates function with a well-defined 3D structure …