Proteins undergoing liquid–liquid phase separation are being discovered at an increasing
rate. Since at the high concentrations present in the cell most proteins would be expected to …

We here attempt to achieve an integrated understanding of the structure and dynamics of a
number of higher-order assemblies, including amyloids, various kinds of signalosomes, and …

Pre-mRNA splicing is catalyzed by the spliceosome, a multimegadalton ribonucleoprotein
(RNP) complex comprised of five snRNPs and numerous proteins. Intricate RNA-RNA and …

Many RNA-binding proteins have modular structures and are composed of multiple repeats
of just a few basic domains that are arranged in various ways to satisfy their diverse …

The RNA recognition motif (RRM), also known as RNA‐binding domain (RBD) or
ribonucleoprotein domain (RNP) is one of the most abundant protein domains in eukaryotes …

The notion that all protein functions are determined through macromolecular interactions is
the driving force behind current efforts that aim to solve the structures of all cellular …

The RNA recognition motif (RRM) is one of the most abundant protein domains in
eukaryotes. While the structure of this domain is well characterized by the packing of two α …

Specific molecular recognition is assumed to require a well-defined set of contacts and
devoid of conformational and interaction ambiguities. Growing experimental evidence …

Most eukaryotic mRNA precursors (premRNAs) must undergo extensive processing,
including cleavage and polyadenylation at the 3′-end. Processing at the 3′-end is …

The existence and functioning of intrinsically disordered proteins (IDPs) challenge the
classical structure-function paradigm that equates function with a well-defined 3D structure …