Lupus nephritis (LN) is a form of glomerulonephritis that constitutes one of the most severe
organ manifestations of the autoimmune disease systemic lupus erythematosus (SLE). Most …

Systemic lupus erythematosus (SLE) is a devastating autoimmune disease that can result in
substantial morbidity and mortality. Diagnosis and treatment of SLE are clinical challenges …

Glomerular disease, be it primary or secondary, occurring in the setting of systemic
autoimmune diseases, infections, drugs, or malignancy, affects individuals of all ages. In …

Objective To update the 2012 EULAR/ERA–EDTA recommendations for the management of
lupus nephritis (LN). Methods Following the EULAR standardised operating procedures, a …

We performed a post hoc analysis of the Belimumab International Study in Lupus Nephritis
(BLISS-LN), a Phase 3, multinational, double-blind, 104-week trial, in which 448 patients …

The global nephrology community recognises the need for a cohesive plan to address the
problem of chronic kidney disease (CKD). In July, 2016, the International Society of …

Ligation of the CD28 receptor on T cells provides a critical second signal alongside T cell
receptor (TCR) ligation for naive T cell activation. Here, we discuss the expression, structure …

Objective To assess the safety, mechanism of action, and preliminary efficacy of rituximab
followed by belimumab in the treatment of refractory lupus nephritis (LN). Methods In a …

Background Systemic lupus erythematosis (SLE) is a complex and clinically heterogeneous
autoimmune disease. A variety of immunological defects contribute to SLE, including …

Systemic lupus erythematosus (SLE) is associated with a broad spectrum of clinical and
immunologic manifestations, of which lupus nephritis is the most common cause of morbidity …