Remodelling of the tumour microenvironment by the kallikrein-related peptidases
Kallikrein-related peptidases (KLKs) are critical regulators of the tumour microenvironment.
KLKs are proteolytic enzymes regulating multiple functions of bioactive molecules including …
KLKs are proteolytic enzymes regulating multiple functions of bioactive molecules including …
Unleashing the therapeutic potential of human kallikrein-related serine proteases
Tissue kallikreins are a family of fifteen secreted serine proteases encoded by the largest
protease gene cluster in the human genome. In the past decade, substantial progress has …
protease gene cluster in the human genome. In the past decade, substantial progress has …
The implications of zinc therapy in combating the COVID-19 global pandemic
N Samad, TE Sodunke, AR Abubakar… - Journal of …, 2021 - Taylor & Francis
The global pandemic from COVID-19 infection has generated significant public health
concerns, both health-wise and economically. There is no specific pharmacological antiviral …
concerns, both health-wise and economically. There is no specific pharmacological antiviral …
Beyond the biomarker role: prostate-specific antigen (PSA) in the prostate cancer microenvironment
The prostate-specific antigen (PSA) blood test is the accepted biomarker of tumor
recurrence. PSA levels in serum correlate with disease progression, though its diagnostic …
recurrence. PSA levels in serum correlate with disease progression, though its diagnostic …
Inhibition of plasma kallikrein by a highly specific active site blocking antibody
JA Kenniston, RR Faucette, D Martik… - Journal of Biological …, 2014 - ASBMB
Plasma kallikrein (pKal) proteolytically cleaves high molecular weight kininogen to generate
the potent vasodilator and the pro-inflammatory peptide, bradykinin. pKal activity is tightly …
the potent vasodilator and the pro-inflammatory peptide, bradykinin. pKal activity is tightly …
Kallikreins–the melting pot of activity and function
M Kalinska, U Meyer-Hoffert, T Kantyka, J Potempa - Biochimie, 2016 - Elsevier
The human tissue kallikrein and kallikrein-related peptidases (KLKs), encoded by the largest
contiguous cluster of protease genes in the human genome, are secreted serine proteases …
contiguous cluster of protease genes in the human genome, are secreted serine proteases …
Characterization, biomedical and agricultural applications of protease inhibitors: A review
Abstract This review describes Protease Inhibitors (PIs) which target or inhibit proteases,
protein digesting enzymes. These proteases play a crucial task in many biological events …
protein digesting enzymes. These proteases play a crucial task in many biological events …
Crystal structures of protein-bound cyclic peptides
Cyclization is an important post-translational modification of peptides and proteins that
confers key advantages such as protection from proteolytic degradation, altered solubility …
confers key advantages such as protection from proteolytic degradation, altered solubility …
Surface loops of trypsin-like serine proteases as determinants of function
P Goettig, H Brandstetter, V Magdolen - Biochimie, 2019 - Elsevier
Trypsin and chymotrypsin-like serine proteases from family S1 (clan PA) constitute the
largest protease group in humans and more generally in vertebrates. The prototypes …
largest protease group in humans and more generally in vertebrates. The prototypes …
The kallikrein-related peptidase family: Dysregulation and functions during cancer progression
Cancer is the second leading cause of death with 14 million new cases and 8.2 million
cancer-related deaths worldwide in 2012. Despite the progress made in cancer therapies …
cancer-related deaths worldwide in 2012. Despite the progress made in cancer therapies …