Acute respiratory distress syndrome

MA Matthay, RL Zemans, GA Zimmerman… - Nature reviews Disease …, 2019 - nature.com
The acute respiratory distress syndrome (ARDS) is a common cause of respiratory failure in
critically ill patients and is defined by the acute onset of noncardiogenic pulmonary oedema …

Contribution of neutrophils to acute lung injury

J Grommes, O Soehnlein - Molecular medicine, 2011 - Springer
Abstract Treatment of acute lung injury (ALI) and its most severe form, acute respiratory
distress syndrome (ARDS), remain unsolved problems of intensive care medicine …

The acute respiratory distress syndrome: pathogenesis and treatment

MA Matthay, RL Zemans - Annual Review of Pathology …, 2011 - annualreviews.org
The acute respiratory distress syndrome (ARDS) causes 40% mortality in approximately
200,000 critically ill patients annually in the United States. ARDS is caused by protein-rich …

Leukocyte–endothelial-cell interactions in leukocyte transmigration and the inflammatory response

WA Muller - Trends in immunology, 2003 - cell.com
Both the innate and adaptive immune responses are dependent on the migration of
leukocytes across endothelial cells. The process of diapedesis, in which the leukocyte …

The lung is a host defense niche for immediate neutrophil-mediated vascular protection

BG Yipp, JH Kim, R Lima, LD Zbytnuik, B Petri… - Science …, 2017 - science.org
Bloodstream infection is a hallmark of sepsis, a medically emergent condition requiring rapid
treatment. However, up-regulation of host defense proteins through Toll-like receptors …

Intercellular adhesion molecule-1 (ICAM-1) expression and cell signaling cascades

AK Hubbard, R Rothlein - Free radical biology and medicine, 2000 - Elsevier
The collective interaction between cells is, in part, mediated by different families of adhesion
molecules. Intercellular adhesion molecules (ICAMs) are structurally related members of the …

The" retinoic acid syndrome" in acute promyelocytic leukemia

SR Frankel, A Eardley, G Lauwers, M Weiss… - Annals of internal …, 1992 - acpjournals.org
▪ Objective: To describe a novel complication of therapy with all-trans retinoic acid in patients
with acute promyelocytic leukemia.▪ Design: Case series.▪ Setting: Comprehensive cancer …

The paradox of the neutrophilˈs role in tissue injury

GB Segel, MW Halterman… - Journal of leukocyte …, 2011 - Wiley Online Library
The neutrophil is an essential component of the innate immune system, and its function is
vital to human life. Its production increases in response to virtually all forms of inflammation …

Transepithelial migration of neutrophils: mechanisms and implications for acute lung injury

RL Zemans, SP Colgan, GP Downey - American journal of …, 2009 - atsjournals.org
The primary function of neutrophils in host defense is to contain and eradicate invading
microbial pathogens. This is achieved through a series of swift and highly coordinated …

The molecular basis of leukocyte recruitment and its deficiencies

S Schmidt, M Moser, M Sperandio - Molecular immunology, 2013 - Elsevier
The innate immune system responds to inflammation, infection and injury by recruiting
neutrophils and other leukocytes. These cells are able to leave the intravascular …