The value of antimicrobial peptides in the age of resistance

M Magana, M Pushpanathan, AL Santos… - The lancet infectious …, 2020 - thelancet.com
Accelerating growth and global expansion of antimicrobial resistance has deepened the
need for discovery of novel antimicrobial agents. Antimicrobial peptides have clear …

Therapeutic compounds targeting Lipid II for antibacterial purposes

JJ Malin, E de Leeuw - Infection and drug resistance, 2019 - Taylor & Francis
Resistance against commonly used antibiotics has emerged in all bacterial pathogens. In
fact, there is no antibiotic currently in clinical use against which resistance has not been …

On-demand reversible UV-triggered interpenetrating polymer network-based drug delivery system using the Spiropyran–Merocyanine hydrophobicity switch

M Ghani, A Heiskanen, J Kajtez, B Rezaei… - … Applied Materials & …, 2021 - ACS Publications
A reversible switchable on-demand UV-triggered drug delivery system (DDS) based on
interpenetrating polymer networks (IPNs) with silicone as the host polymer and spiropyran …

Antibacterial, Anti-biofilm and pro-migratory effects of double layered hydrogels packaged with lactoferrin-DsiRNA-silver nanoparticles for chronic wound therapy

MAM Fathil, H Katas - Pharmaceutics, 2023 - mdpi.com
Antimicrobial resistance and biofilm formation in diabetic foot infections worsened during the
COVID-19 pandemic, resulting in more severe infections and increased amputations …

[HTML][HTML] Ultrasonic-assisted manufacturing of new hydrogel nanocomposite biosorbent containing calcium carbonate nanoparticles and tragacanth gum for removal of …

S Mallakpour, A Abdolmaleki, F Tabesh - Ultrasonics Sonochemistry, 2018 - Elsevier
This article reports the first incorporation of calcium carbonate nanoparticles (CC NPs) into
tragacanth gum (TG) to prepare a new hydrogel nanocomposite (HNC) system using a …

A recombinant fungal defensin-like peptide-P2 combats multidrug-resistant Staphylococcus aureus and biofilms

N Yang, D Teng, R Mao, Y Hao, X Wang… - Applied microbiology …, 2019 - Springer
There is an urgent need to discover new active drugs to combat methicillin-resistant
Staphylococcus aureus, which is a serious threat to humans and animals and incompletely …

pH-and concentration-dependent supramolecular assembly of a fungal defensin plectasin variant into helical non-amyloid fibrils

C Pohl, G Effantin, E Kandiah, S Meier, G Zeng… - Nature …, 2022 - nature.com
Self-assembly and fibril formation play important roles in protein behaviour. Amyloid fibril
formation is well-studied due to its role in neurodegenerative diseases and characterized by …

Effect of NZ2114 against Streptococcus dysgalactiae biofilms and its application in murine mastitis model

N Yang, Q Zhang, R Mao, Y Hao, X Ma… - Frontiers in …, 2022 - frontiersin.org
Bovine mastitis caused by Streptococcus dysgalactiae (S. dysgalactiae) is usually treated
with antibiotics, which may potentially increase drug resistance as the abuse. NZ2114, a …

In Vitro/Vivo Mechanisms of Antibacterial Peptide NZ2114 against Staphylococcus pseudintermedius and Its Biofilms

S Zhang, N Yang, R Mao, Y Hao, D Teng, J Wang - Antibiotics, 2024 - mdpi.com
Staphylococcus pseudintermedius is an opportunistic pathogen commonly found in canines,
and has garnered escalating interest due to its potential for zoonotic transmission and …

A novel device-integrated drug delivery system for local inhibition of urinary tract infection

K Stærk, RB Grønnemose, Y Palarasah… - Frontiers in …, 2021 - frontiersin.org
Background: Catheter-associated urinary tract infection (CAUTI) is a frequent community-
acquired infection and the most common nosocomial infection. Here, we developed a novel …