Incorporating ecology into gene drive modelling

J Kim, KD Harris, IK Kim, S Shemesh… - Ecology …, 2023 - Wiley Online Library
Gene drive technology, in which fast‐spreading engineered drive alleles are introduced into
wild populations, represents a promising new tool in the fight against vector‐borne diseases …

Next-generation gene drive for population modification of the malaria vector mosquito, Anopheles gambiae

R Carballar-Lejarazú, C Ogaugwu… - Proceedings of the …, 2020 - National Acad Sciences
A Cas9/guide RNA-based gene drive strain, AgNosCd-1, was developed to deliver
antiparasite effector molecules to the malaria vector mosquito, Anopheles gambiae. The …

Eliminating malaria vectors with precision-guided sterile males

RA Apte, AL Smidler, JJ Pai, ML Chow, S Chen… - Proceedings of the …, 2024 - pnas.org
Controlling the principal African malaria vector, the mosquito Anopheles gambiae, is
considered essential to curtail malaria transmission. However, existing vector control …

Selective targeting of biting females to control mosquito-borne infectious diseases

BB Kojin, A Compton, ZN Adelman, Z Tu - Trends in parasitology, 2022 - cell.com
Mosquitoes are vectors for a number of infectious diseases. Only females feed on blood to
provision for their embryos and, in doing so, transmit pathogens to the associated vertebrate …

High-resolution transcriptional profiling of Anopheles gambiae spermatogenesis reveals mechanisms of sex chromosome regulation

C Taxiarchi, N Kranjc, A Kriezis, K Kyrou… - Scientific reports, 2019 - nature.com
Although of high priority for the development of genetic tools to control malaria-transmitting
mosquitoes, only a few germline-specific regulatory regions have been characterised to date …

Adequacy and sufficiency evaluation of existing EFSA guidelines for the molecular characterisation, environmental risk assessment and post‐market environmental …

EFSA Panel on Genetically Modified Organisms … - Efsa …, 2020 - Wiley Online Library
Advances in molecular and synthetic biology are enabling the engineering of gene drives in
insects for disease vector/pest control. Engineered gene drives (that bias their own …

[HTML][HTML] CRISPR/Cas9 knockout of female-biased genes AeAct-4 or myo-fem in Ae. aegypti results in a flightless phenotype in female, but not male mosquitoes

S O'Leary, ZN Adelman - PLOS Neglected Tropical Diseases, 2020 - journals.plos.org
Aedes aegypti is a vector of dengue, chikungunya, and Zika viruses. Current vector control
strategies such as community engagement, source reduction, and insecticides have not …

Evaluating the probability of CRISPR‐based gene drive contaminating another species

V Courtier‐Orgogozo, A Danchin… - Evolutionary …, 2020 - Wiley Online Library
The probability D that a given clustered regularly interspaced short palindromic repeats
(CRISPR)‐based gene drive element contaminates another, nontarget species can be …

[HTML][HTML] Eliminating malaria vectors with precision guided sterile males

AL Smidler, RA Apte, JJ Pai, ML Chow, S Chen… - bioRxiv, 2023 - ncbi.nlm.nih.gov
Controlling the principal African malaria vector, the mosquito Anopheles gambiae, is
considered essential to curtail malaria transmission. However existing vector control …

Relative expression of key genes involved in nucleic acids methylation in Anopheles gambiae sensu stricto

OY Djihinto, D Meacci, AA Medjigodo… - Medical and …, 2023 - Wiley Online Library
In vertebrates, enzymes responsible for DNA methylation, one of the epigenetic
mechanisms, are encoded by genes falling into the cytosine methyltransferases genes …