Toll-like receptors in immunity and inflammatory diseases: Past, present, and future

K Vijay - International immunopharmacology, 2018 - Elsevier
The immune system is a very diverse system of the host that evolved during evolution to
cope with various pathogens present in the vicinity of environmental surroundings inhabited …

The role of TLRs in anti-cancer immunity and tumor rejection

Z Urban-Wojciuk, MM Khan, BL Oyler… - Frontiers in …, 2019 - frontiersin.org
In recent years, a lot of scientific interest has focused on cancer immunotherapy. Although
chronic inflammation has been described as one of the hallmarks of cancer, acute …

Periodontal disease and cancer: Epidemiologic studies and possible mechanisms

N Nwizu, J Wactawski‐Wende… - Periodontology 2000, 2020 - Wiley Online Library
Epidemiologic and cancer control studies on the association of periodontal disease and
cancer risk mostly suggest a positive association with overall cancer risk and certain specific …

Toll-like receptor-guided therapeutic intervention of human cancers: molecular and immunological perspectives

S Mukherjee, R Patra, P Behzadi, A Masotti… - Frontiers in …, 2023 - frontiersin.org
Toll-like receptors (TLRs) serve as the body's first line of defense, recognizing both
pathogen-expressed molecules and host-derived molecules released from damaged or …

Mechanisms and pathways of innate immune activation and regulation in health and cancer

J Cui, Y Chen, HY Wang, RF Wang - Human vaccines & …, 2014 - Taylor & Francis
Research on innate immune signaling and regulation has recently focused on pathogen
recognition receptors (PRRs) and their signaling pathways. Members of PRRs sense …

Targeting toll-like receptor 7/8 for immunotherapy: recent advances and prospectives

H Sun, Y Li, P Zhang, H Xing, S Zhao, Y Song… - Biomarker …, 2022 - Springer
Toll-like receptors (TLRs) are a large family of proteins that are expressed in immune cells
and various tumor cells. TLR7/8 are located in the intracellular endosomes, participate in …

AIPpred: sequence-based prediction of anti-inflammatory peptides using random forest

B Manavalan, TH Shin, MO Kim, G Lee - Frontiers in pharmacology, 2018 - frontiersin.org
The use of therapeutic peptides in various inflammatory diseases and autoimmune
disorders has received considerable attention; however, the identification of anti …

Toll-like receptor stimulation in cancer: a pro-and anti-tumor double-edged sword

M Dajon, K Iribarren, I Cremer - Immunobiology, 2017 - Elsevier
Toll-like receptors (TLRs) are a family of transmembrane receptors that recognize various
pathogen-and damage-associated molecular pattern molecules playing an important role in …

Toll‐Like Receptor‐Based Strategies for Cancer Immunotherapy

S Pahlavanneshan, A Sayadmanesh… - Journal of …, 2021 - Wiley Online Library
Toll‐like receptors (TLRs) are expressed and play multiple functional roles in a variety of
immune cell types involved in tumor immunity. There are plenty of data on the …

Modulation of the innate immune response by targeting toll-like receptors: a perspective on their agonists and antagonists

S Federico, L Pozzetti, A Papa, G Carullo… - Journal of Medicinal …, 2020 - ACS Publications
Toll-like receptors (TLRs) are a class of proteins that recognize pathogen-associated
molecular patterns (PAMPs) and damaged-associated molecular patterns (DAMPs), and …