The skin microbial community is a multifunctional ecosystem aiding prevention of infections
from transient pathogens, maintenance of host immune homeostasis, and skin health. A …

The underlying mechanism of seborrheic dermatitis (SD) is poorly understood but major
scientific progress has been made in recent years related to microbiology, immunology and …

Seborrhoeic Dermatitis (SD) is a very common chronic and/or relapsing inflammatory skin
disorder whose pathophysiology remains poorly understood. Yeast of the genus Malassezia …

Pruritus represents one of the most common symptoms in dermatology and general
medicine. Chronic pruritus severely impairs the quality of life of affected patients. During the …

Since its discovery, the Hippo pathway has emerged as a central signaling network in
mammalian cells. Canonical signaling through the Hippo pathway core components …

The thymus prevents autoimmune diseases through mechanisms that operate in the cortex
and medulla, comprising positive and negative selection and the generation of regulatory T …

The Hippo signaling pathway has been established as a key regulator of organ size control,
tumor suppression, and tissue regeneration in multiple organisms. Recently, emerging …

The Hippo pathway was originally identified as an evolutionarily-conserved signaling
mechanism that contributes to the control of organ size. It was then rapidly expanded as a …

The MST1 and MST2 protein kinases comprise the GCK-II subfamily of protein kinases. In
addition to their amino-terminal kinase catalytic domain, related to that of the …

An increasing number of primary immunodeficiencies (PIDs) have been identified over the
last decade, which are caused by deleterious mutations in genes encoding for proteins …