Extracellular matrix (ECM) structures within skeletal muscle play an important, but under-
appreciated, role in muscle development, function and adaptation. Each individual muscle is …

Skeletal muscle is critical for human health. Protein feeding, alongside resistance exercise,
is a potent stimulus for muscle protein synthesis (MPS) and is a key factor that regulates …

Substantial divergence in cardio-metabolic risk, muscle size, and performance exists
between men and women. Considering the pivotal role of skeletal muscle in human …

Skeletal muscle metabolic and contractile properties are reliant on muscle mitochondrial
and myofibrillar protein turnover. The turnover of these specific protein pools is …

Protein synthesis and autophagy are regulated by cellular ATP content. We tested the
hypothesis that mitochondrial dysfunction, including generation of reactive oxygen species …

Background Successful strategies to halt or reverse sarcopenia require a basic
understanding of the factors that cause muscle loss with age. Acute periods of muscle loss in …

Purpose: It is well established that high-load resistance exercise (HLRE) can stimulate
myofibrillar accretion. Additionally, recent studies suggest that HLRE can also stimulate …

The use of deuterium oxide (D2O) has greatly expanded the scope of what is possible for
the measurement of protein synthesis. The greatest asset of D2O labeling is that it facilitates …

Age-related deterioration in turnover of collagen proteins accelerates extracellular matrix
fibrosis and hinders adaptation to external stimuli. This project sought to understand factors …

Background Translational capacity (ie ribosomal mass) is a key determinant of protein
synthesis and has been associated with skeletal muscle hypertrophy. The role of …