Melatonin promotes uterine and placental health: potential molecular mechanisms

LG de Almeida Chuffa, LA Lupi, MS Cucielo… - International journal of …, 2019 - mdpi.com
The development of the endometrium is a cyclic event tightly regulated by hormones and
growth factors to coordinate the menstrual cycle while promoting a suitable …

Melatonin and myo-inositol: Supporting reproduction from the oocyte to birth

M Russo, G Forte, M Montanino Oliva… - International journal of …, 2021 - mdpi.com
Human pregnancy is a sequence of events finely tuned by several molecular interactions
that come with a new birth. The precise interlocking of these events affecting the …

Melatonin protects against thoracic aortic aneurysm and dissection through SIRT1‐dependent regulation of oxidative stress and vascular smooth muscle cell loss

L Xia, C Sun, H Zhu, M Zhai, L Zhang… - Journal of pineal …, 2020 - Wiley Online Library
Melatonin functions as an endogenous protective molecule in multiple vascular diseases,
whereas its effects on thoracic aortic aneurysm and dissection (TAAD) and underlying …

The ameliorative effect of melatonin on LPS-induced Sertoli cells inflammatory and tight junctions damage via suppression of the TLR4/MyD88/NF-κB signaling …

R Feng, SO Adeniran, F Huang, Y Li, M Ma, P Zheng… - Theriogenology, 2022 - Elsevier
The blood-testicular barrier (BTB) is involved in spermatogenesis, protects sperm
development, and plays a crucial role in the reproductive process. Tight junctions (TJs) …

Circadian clock-controlled checkpoints in the pathogenesis of complex disease

MD Li, H Xin, Y Yuan, X Yang, H Li, D Tian… - Frontiers in …, 2021 - frontiersin.org
The circadian clock coordinates physiology, metabolism, and behavior with the 24-h cycles
of environmental light. Fundamental mechanisms of how the circadian clock regulates organ …

Pterostilbene exerts hepatoprotective effects through ameliorating LPS/D-Gal-induced acute liver injury in mice

Z Liu, J Wang, Y Zhang, D Wu, S Li, A Jiang, CT Du… - Inflammation, 2021 - Springer
Acute liver injury (ALI) refers to abnormalities in liver function caused by various causes and
accompanied by poor prognosis and high mortality. Common predisposing factors for the …

Exogenous melatonin protects preimplantation embryo development from decabromodiphenyl ethane-induced circadian rhythm disorder and endogenous melatonin …

F Shi, J Qiu, S Zhang, X Zhao, D Feng, X Feng - Environmental Pollution, 2022 - Elsevier
Decabromodiphenyl ethane (DBDPE) is a novel flame retardant that is widely used in
plastics, electronic products, building materials and textiles. Our previous studies have …

Supraphysiological role of melatonin over vascular dysfunction of pregnancy, a new therapeutic agent?

FJ Valenzuela-Melgarejo, C Lagunas… - Frontiers in …, 2021 - frontiersin.org
Hypertension can be induced by the disruption of factors in blood pressure regulation. This
includes several systems such as Neurohumoral, Renin-angiotensin-aldosterone, the …

Effects of melatonin supplementation during pregnancy on reproductive performance, maternal–placental–fetal redox status, and placental mitochondrial function in a …

X Peng, X Cai, J Li, Y Huang, H Liu, J He, Z Fang… - Antioxidants, 2021 - mdpi.com
Melatonin (MT) is a bio-antioxidant that has been widely used to prevent pregnancy
complications, such as pre-eclampsia and IUGR during gestation. This experiment …

Lysine specific demethylase 1 inhibitor alleviated lipopolysaccharide/D-galactosamine-induced acute liver injury

X Wang, Y Sun, Y Fu, H Wu, Y Chen, Y Ye… - European Journal of …, 2022 - Elsevier
Acute liver injury is a severe clinical syndrome with markedly high mortality and poor
prognosis. An accumulating body of evidence has demonstrated that epigenetic …