The cell microenvironment has emerged as a key determinant of cell behavior and function
in development, physiology, and pathophysiology. The extracellular matrix (ECM) within the …

Collective cell migration results from the establishment and maintenance of collective
polarization, mechanocoupling, and cytoskeletal kinetics. The guidance of collective cell …

Communities of epithelial cells communicate through intercellular interactions, allowing
them to coordinate their motility, which plays a key role in homeostasis, morphogenesis and …

Many cells are small and rounded on soft extracellular matrices (ECM), elongated on stiffer
ECMs, and flattened on hard ECMs. Cells also migrate up stiffness gradients (durotaxis) …

Although directed migration of eukaryotic cells may have evolved to escape nutrient
depletion, it has been adopted for an extensive range of physiological events during …

This study investigated how substrate geometry influences in-vitro tissue formation at length
scales much larger than a single cell. Two-millimetre thick hydroxyapatite plates containing …

Filopodia have a key role in sensing both chemical and mechanical cues in surrounding
extracellular matrix (ECM). However, quantitative understanding is still missing in the …

Background Wound healing is the first stage of a series of cellular events that are necessary
to initiate a regenerative response. Defective wound healing can block regeneration even in …

Within the past 25 years, tissue engineering (TE) has grown enormously as a science and
as an industry. Although classically concerned with the recapitulation of tissue and organ …

Cells in the human body experience and integrate a wide variety of environmental cues. A
growing interest in tissue mechanics in the past four decades has shown that the …