Targeting Nrf2/Keap1 signaling pathway by bioactive natural agents: Possible therapeutic strategy to combat liver disease
Background Nuclear factor erythroid 2-related factor (Nrf2), a stress-activated transcription
factor, has been documented to induce a defense mechanism against oxidative stress …
factor, has been documented to induce a defense mechanism against oxidative stress …
[HTML][HTML] Role of Nrf2 in chronic liver disease
W Tang, YF Jiang, M Ponnusamy… - World journal of …, 2014 - ncbi.nlm.nih.gov
Abstract Nuclear erythroid 2-related factor 2 (Nrf2) is a central regulator of antioxidative
response elements-mediated gene expression. It has a significant role in adaptive …
response elements-mediated gene expression. It has a significant role in adaptive …
Parabacteroides distasonis ameliorates hepatic fibrosis potentially via modulating intestinal bile acid metabolism and hepatocyte pyroptosis in male mice
Q Zhao, MY Dai, RY Huang, JY Duan, T Zhang… - Nature …, 2023 - nature.com
Parabacteroides distasonis (P. distasonis) plays an important role in human health,
including diabetes, colorectal cancer and inflammatory bowel disease. Here, we show that …
including diabetes, colorectal cancer and inflammatory bowel disease. Here, we show that …
Hepatic 3D spheroid models for the detection and study of compounds with cholestatic liability
DFG Hendriks, L Fredriksson Puigvert, S Messner… - Scientific reports, 2016 - nature.com
Drug-induced cholestasis (DIC) is poorly understood and its preclinical prediction is mainly
limited to assessing the compound's potential to inhibit the bile salt export pump (BSEP) …
limited to assessing the compound's potential to inhibit the bile salt export pump (BSEP) …
Naturally occurring Nrf2 activators: potential in treatment of liver injury
Oxidative stress plays a major role in acute and chronic liver injury. In hepatocytes, oxidative
stress frequently triggers antioxidant response by activating nuclear erythroid 2‐related …
stress frequently triggers antioxidant response by activating nuclear erythroid 2‐related …
Strong inhibitory activity and action modes of synthetic maslinic acid derivative on highly pathogenic coronaviruses: COVID-19 drug candidate
In late December 2019, a novel coronavirus, namely severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2), escaped the animal–human interface and emerged as an …
coronavirus 2 (SARS-CoV-2), escaped the animal–human interface and emerged as an …
Oleanolic acid alleviates ANIT-induced cholestatic liver injury by activating Fxr and Nrf2 pathways to ameliorate disordered bile acids homeostasis
J Liu, J Liu, C Meng, C Huang, F Liu, C Xia - Phytomedicine, 2022 - Elsevier
Background Cholestasis is a clinical syndrome with high incidence and few effective
treatments. Oleanolic acid (OA) is a triterpenoid compound with anti-cholestatic effects …
treatments. Oleanolic acid (OA) is a triterpenoid compound with anti-cholestatic effects …
Antiviral activities of oleanolic acid and its analogues
Viral diseases, such as human immune deficiency virus (HIV), influenza, hepatitis, and
herpes, are the leading causes of human death in the world. The shortage of effective …
herpes, are the leading causes of human death in the world. The shortage of effective …
Sterols and triterpenes: Antiviral potential supported by in-silico analysis
The acute respiratory syndrome caused by the novel coronavirus (SARS-CoV-2) caused
severe panic all over the world. The coronavirus (COVID-19) outbreak has already brought …
severe panic all over the world. The coronavirus (COVID-19) outbreak has already brought …
NRF2 and FXR dual signaling pathways cooperatively regulate the effects of oleanolic acid on cholestatic liver injury
J Liu, J Liu, C Meng, Q Gu, C Huang, F Liu, C Xia - Phytomedicine, 2023 - Elsevier
Background Previous studies have shown that the anti-cholestatic effect of oleanolic acid
(OA) is associated with FXR and NRF2. However, how the two signaling pathways …
(OA) is associated with FXR and NRF2. However, how the two signaling pathways …