One hundred years ago, Ramón y Cajal, considered by many as the founder of modern
neuroscience, stated that neurons of the adult central nervous system (CNS) are incapable …

Neurons of the mammalian central nervous system fail to regenerate. Substantial progress
has been made toward identifying the cellular and molecular mechanisms that underlie …

Single-cell transcriptomics provide a systematic map of gene expression in different human
cell types. The next challenge is to systematically understand cell-type-specific gene …

CRISPR/Cas9-based functional genomics have transformed our ability to elucidate
mammalian cell biology. However, most previous CRISPR-based screens were conducted …

The eye is regarded as an immune privileged site. Since the presence of a vasculature
would impair vision, the vasculature of the eye is located outside of the central light path. As …

Retinal ganglion cells (RGCs) are the sole output neurons that transmit visual information
from the retina to the brain. Diverse insults and pathological states cause degeneration of …

Glaucoma is the most prevalent neurodegenerative disease and a leading cause of
blindness worldwide. The mechanisms causing glaucomatous neurodegeneration are not …

Neuroinflammation and necroptosis are major contributors to neurodegenerative disease,
and axon dysfunction and degeneration is often an initiating event. SARM1 is the central …

Synapse dysfunction and loss are hallmarks of neurodegenerative diseases that correlate
with cognitive decline. However, the mechanisms and therapeutic strategies to prevent or …

Pluripotent stem cells (PSCs) hold great promise for drug discovery and regenerative
medicine owing to their ability to differentiate into any cell type in the body. After more than …