Background The global rise of metabolic disorders, such as obesity, type 2 diabetes, and
cardiovascular disease, demands a thorough molecular understanding of the cellular …

The pathogenesis of non-alcoholic fatty liver disease, particularly the mechanisms whereby
a minority of patients develop a more severe phenotype characterised by hepatocellular …

Nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH) remain
without effective therapies. The mechanistic target of rapamycin complex 1 (mTORC1) …

Autophagy captures intracellular components and delivers them to lysosomes, where they
are degraded and recycled to sustain metabolism and to enable survival during starvation …

Background The incidence of non-alcoholic fatty liver disease (NAFLD) is rapidly increasing
worldwide parallel to the global obesity epidemic. NAFLD encompasses a range of liver …

Lifestyle modifications focused on healthy eating and regular exercise are the primary
recommendations for patients with nonalcoholic steatohepatitis (NASH). However, for …

The gut microbiota is a key environmental determinant of mammalian metabolism.
Regulation of white adipose tissue (WAT) by the gut microbiota is a process critical to …

Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease and
represents the hepatic expression of several metabolic abnormalities of high epidemiologic …

Vitamin A is required for important physiological processes, including embryogenesis,
vision, cell proliferation and differentiation, immune regulation, and glucose and lipid …

Nonalcoholic fatty liver disease (NAFLD) represents a growing cause of chronic liver injury,
especially in western countries, where it is becoming the most frequent indication for liver …