Retinitis pigmentosa is an incurable retinal disease that leads to blindness. One puzzling
aspect concerns the progression of the disease. Although most mutations that cause retinitis …

Mice express S and M opsins that form visual pigments for the detection of light and visual
signaling in cones. Here, we show that S opsin transcription is higher than that of M opsin …

As a complementary approach to positional cloning, we used in vivo complementation with
bacterial artificial chromosome (BAC) clones expressed in transgenic mice to identify the …

Retinal degeneration in the mouse mutant, rd, was previously shown to be a disorder of
cyclic nucleotide metabolism involving a deficiency in the activity of the rod photoreceptor …

We inserted into the germline of mice either a mutant or wild-type allele from a patient with
retinitis pigmentosa and a missense mutation (P23H) in the rhodop sin gene. All three lines …

The chicken retina contains rhodopsin (a rod visual pigment) and four kinds of cone visual
pigments. The primary structures of chicken red (iodopsin) and rhodopsin have been …

Irish setter dogs affected with a rod/cone dysplasia (locus designation, rcd1) display
markedly elevated levels of retinal cGMP during postnatal development. The photoreceptor …

We have previously shown that postnatal expression of the viral oncoprotein SV40 T antigen
in rod photoreceptors (transgene MOT1), at a time when retinal cells have withdrawn from …

Autosomal dominant retinitis pigmentosa (ADRP), slowly progressing over decades, leads to
severe visual impairment and in some cases to complete blindness. More than 40 mutations …

Retinal photoreceptors are highly differentiated postmitotic neurons that transduce photons
into electrical signals. While the functions of many photoreceptor‐specific genes can be …