Lost in translation: the valley of death across preclinical and clinical divide–identification of problems and overcoming obstacles
AA Seyhan - Translational Medicine Communications, 2019 - Springer
A rift that has opened up between basic research (bench) and clinical research and patients
(bed) who need their new treatments, diagnostics and prevention, and this rift is widening …
(bed) who need their new treatments, diagnostics and prevention, and this rift is widening …
Chemosensory signal transduction in Caenorhabditis elegans
DM Ferkey, P Sengupta, ND L'Etoile - Genetics, 2021 - academic.oup.com
Chemosensory neurons translate perception of external chemical cues, including odorants,
tastants, and pheromones, into information that drives attraction or avoidance motor …
tastants, and pheromones, into information that drives attraction or avoidance motor …
Seaweed extract stimuli in plant science and agriculture
JS Craigie - Journal of applied phycology, 2011 - Springer
Both micro-and macroalgae have long been used to augment plant productivity and food
production in various regions of the world through their beneficial effects when applied to …
production in various regions of the world through their beneficial effects when applied to …
C. elegans in high-throughput drug discovery
LP O'Reilly, CJ Luke, DH Perlmutter… - Advanced drug delivery …, 2014 - Elsevier
Caenorhabditis elegans has been proven to be a useful model organism for investigating
molecular and cellular aspects of numerous human diseases. More recently, investigators …
molecular and cellular aspects of numerous human diseases. More recently, investigators …
Caenorhabditis elegans is a useful model for anthelmintic discovery
Parasitic nematodes infect one quarter of the world's population and impact all humans
through widespread infection of crops and livestock. Resistance to current anthelmintics has …
through widespread infection of crops and livestock. Resistance to current anthelmintics has …
High‐throughput screening and small animal models, where are we?
J Giacomotto, L Ségalat - British journal of pharmacology, 2010 - Wiley Online Library
Current high‐throughput screening methods for drug discovery rely on the existence of
targets. Moreover, most of the hits generated during screenings turn out to be invalid after …
targets. Moreover, most of the hits generated during screenings turn out to be invalid after …
Drug discovery: Insights from the invertebrate Caenorhabditis elegans
S Giunti, N Andersen, D Rayes… - Pharmacology …, 2021 - Wiley Online Library
Therapeutic drug development is a long, expensive, and complex process that usually takes
12–15 years. In the early phases of drug discovery, in particular, there is a growing need for …
12–15 years. In the early phases of drug discovery, in particular, there is a growing need for …
Calcium and cyclic AMP promote axonal regeneration in Caenorhabditis elegans and require DLK-1 kinase
A Ghosh-Roy, Z Wu, A Goncharov, Y Jin… - Journal of …, 2010 - Soc Neuroscience
Axons of adult Caenorhabditis elegans neurons undergo robust regenerative growth after
laser axotomy. Here we show that axotomy of PLM sensory neurons triggers axonal calcium …
laser axotomy. Here we show that axotomy of PLM sensory neurons triggers axonal calcium …
Treatment with paeoniflorin increases lifespan of Pseudomonas aeruginosa infected Caenorhabditis elegans by inhibiting bacterial accumulation in intestinal lumen …
Y Wang, L Zhang, X Yuan, D Wang - Frontiers in Pharmacology, 2023 - frontiersin.org
Paeoniflorin is one of the important components in Paeoniaceae plants. In this study, we
used Caenorhabditis elegans as a model host and Pseudomonas aeruginosa as a bacterial …
used Caenorhabditis elegans as a model host and Pseudomonas aeruginosa as a bacterial …
High-throughput imaging of neuronal activity in Caenorhabditis elegans
J Larsch, D Ventimiglia… - Proceedings of the …, 2013 - National Acad Sciences
Neuronal responses to sensory inputs can vary based on genotype, development,
experience, or stochastic factors. Existing neuronal recording techniques examine a single …
experience, or stochastic factors. Existing neuronal recording techniques examine a single …