It has taken four decades of research to see the first major breakthrough for KRAS-driven
cancers. In particular, the last decade has seen a paradigm shift with the discovery of …

Mutations in KRAS are among the most frequent aberrations in cancer, including colon
cancer. KRAS direct targeting is daunting due to KRAS protein resistance to small molecule …

Long non-coding RNAs (lncRNAs) have been identified as important participants in several
biological functions, particularly their complex interactions with the KRAS pathway, which …

KRAS mutation is responsible for 40–50% of colorectal cancers (CRCs). RNA-seq data and
bioinformatics methods were used to analyze the transcriptional profiles of KRAS mutant …

The KRAS mutation stands out as one of the most influential oncogenic mutations, which
directly regulates the hallmark features of cancer and interacts with other cancer-causing …

Background Colorectal cancer is one of the most prevalent malignancies and its molecular
pathogenesis has been intensely investigated for several decades. As a result, great …

As a member of small GTPase family, KRAS protein is a key physiological modulator of
various cellular activities including proliferation. However, mutations of KRAS present in …

Purpose This study aimed to evaluate the molecular features of clear cell adenocarcinoma
(CCA) of the urinary tract and investigate its pathogenic pathways and possible actionable …

Background PDAC, also known as pancreatic ductal adenocarcinoma, is often diagnosed at
a late stage due to nonspecific symptoms and a distinct lack of reliable biomarkers for timely …

KRAS is one of the most widely prevalent proto-oncogenes in human cancers. The
constitutively active KRAS oncoprotein contributes to both tumor onset and cancer …