γ-Aminobutyrate (GABA) is a major inhibitory neurotransmitter in the adult mammalian brain.
GABA is also considered to be a multifunctional molecule that has different situational …

The GABAA receptor is a ligand-operated chloride channel. It has a pentameric structure. In
mammalian brain different subunits are recruited from four gene subfamilies. Using …

Genetic background of the T cell can influence T helper (Th) phenotype development, with
some murine strains (eg, B10. D2) favoring Th1 development and others (eg, BALB/c) …

Between 1987 and 1989, the different protein subunits that make up the receptor for the
inhibitory neurotransmitter γ-aminobutyric acid (GABA) were identified. These make up the …

The transcription factor IRF-1 has been implicated in tumor suppression: IRF-1 suppresses
cell transformation and mediates apoptosis in vitro. Here we show that the loss of IRF-1 …

Diazepam and abecarnil produce their overt effects by interaction with the GABAA receptor.
Chronic treatment with abecarnil, however, does not induce diazepam-like tolerance. This …

Three genes (Gabrg3, Gabra5, and Gabrb3) encoding the gamma 3, alpha 5, and beta 3
subunits of the type A gamma-aminobutyric acid receptor, respectively, are known to map …

Recombinant inbred (RI) strains derived from the C57BL/6J and A/J mouse strains were
used for behavioral studies designed to estimate the number and location of chromosomal …

LOK is a new and unique member of the STE20 family with serine/threonine kinase activity,
and its expression is restricted mostly to lymphoid cells in mice. We cloned the cDNA …

Th phenotype development is controlled not only by cytokines but also by other parameters
including genetic background. One site of genetic variation between murine strains that has …