While cost-effective high-throughput technologies provide an increasing amount of data, the
analyses of single layers of data seldom provide causal relations. Multi-omics data …

Recent breakthrough results from immune checkpoint inhibitors (ICI) have paved the way to
a new era of cancer immunotherapy. In particular, inhibition of programmed death-1 (PD …

Background The programmed death receptor ligand 1 (PD-L1) immunohistochemistry (IHC)
22C3 pharmDx assay is a widely used selection method for pembrolizumab treatment in …

Large oncology repositories have paired genomic and transcriptomic data for all patients.
We used these data to perform two independent analyses: to identify gene expression …

Gastric cancer (GC), with a heterogeneous nature, is the third leading cause of death
worldwide. Over the past few decades, stable reductions in the incidence of GC have been …

Weighted correlation network analysis (WGCNA) is a statistical method that has been widely
used in recent years to explore gene co-expression modules. Competing endogenous RNA …

Highlights•The identification of oncogenic drivers offers the opportunity to develop target-
specific drugs.•The inhibition of crucial pathways realizes the principle of druggable target to …

Whole exome sequencing (WES) enables the analysis of all protein coding sequences in
the human genome. This technology enables the investigation of cancer-related genetic …

Colorectal cancer (CRC) is one of the most lethal cancers of the digestive system. The tumor
microenvironment (TME) plays a central role in the initiation and development of CRC …

Background Liver cancer is one of the most common cancers and causes of cancer death
worldwide. The objective was to elucidate novel hub genes which were benefit for …