Of the various types of hemophilia, the most common of these lifelong bleeding disorders
are due to an inherited deficiency of factor VIII or factor IX (Table 1). The genes for these …

The dramatic hemorrhages, the effect of the disease on history through its presence in
Queen Victoria's descendants, and the devastating role of therapeutic concentrates in the …

The antibody Fc region regulates antibody cytotoxic activities and serum half-life. In a
therapeutic context, however, the cytotoxic effector function of an antibody is often not …

We have developed a novel" real time" quantitative PCR method. The method measures
PCR product accumulation through a dual-labeled fluorogenic probe (ie, TaqMan Probe) …

Immunoglobulin G (IgG) Fc receptors play a critical role in linking IgG antibody-mediated
immune responses with cellular effector functions. A high resolution map of the binding site …

Rituxan (Rituximab) is a chimeric mAb with human IgG1 constant domains used in the
therapy of non-Hodgkin's B cell lymphomas. This Ab targets B cells by binding to the cell …

Antibody charge variants have gained considerable attention in the biotechnology industry
due to their potential influence on stability and biological activity. Subtle differences in the …

Secretory immunoglobulin A (sIgA) represents the immune system's first line of defense
against mucosal pathogens. IgAs are transported across the epithelium, as dimers and …

Obtaining full-length antibody heavy-and light-chain variable regions from individual B cells
at scale remains a challenging problem. Here we use high-throughput single-cell B-cell …

Humoral hypercalcemia of malignancy is a common complication of lung and certain other
cancers. The hypercalcemia results from the actions of tumor factors on bone and kidney …