Precision medicine is part of five focus areas of the Challenges in IBD research document,
which also includes preclinical human IBD mechanisms, environmental triggers, novel …

Background: The contemporary management of ambulatory ulcerative colitis (UC) continues
to be challenging with∼ 20% of children needing a colectomy within childhood years. We …

Evaluating progression risk and determining optimal therapy for ulcerative colitis (UC) is
challenging as many patients exhibit incomplete responses to treatment. As part of the …

Molecular mechanisms driving disease course and response to therapy in ulcerative colitis
(UC) are not well understood. Here, we use RNAseq to define pre-treatment rectal gene …

INTRODUCTION Tissue homeostasis requires the coordinated activity of multiple cell types
to initiate and then resolve inflammation. Endoplasmic reticulum (ER) stress is a hallmark of …

Methods: These guidelines are a joint effort of the European Crohn's and Colitis
Organization (ECCO) and the European Society of Paediatric Gastroenterology, Hepatology …

Currently, the main targets of drug therapy for ulcerative colitis [UC] are endoscopic and
clinical remission. However, there is active discussion about the additional advantages of …

Background Lack of evidence-based outcomes data leads to uncertainty in developing
treatment regimens in children who are newly diagnosed with ulcerative colitis. We …

Rates of inflammatory bowel disease (IBD) in Canadian children and adolescents are
among the highest in the world, and the incidence is rising most rapidly in children under …

Understanding the role of the microbiome in inflammatory diseases requires the
identification of microbial effector molecules. We established an approach to link disease …