Interleukins and associated cytokines serve as the means of communication for innate and
adaptive immune cells as well as non-immune cells and tissues. Thus, interleukins have a …

Nuclear Factor-kappa B (NF-κB) is a transcription factor family that regulates a large number
of genes that are involved in important physiological processes, including survival …

Background Pancreatic cancer is one of the most lethal human cancers. N 6-
methyladenosine (m 6 A), a common eukaryotic mRNA modification, plays critical roles in …

Adoptive therapy with chimeric antigen receptor (CAR)-redirected T cells has achieved
remarkable efficacy in the treatment of hematopoietic malignancies. However, eradicating …

T-cell exhaustion is a phenomenon that represents the dysfunctional state of T cells in
chronic infections and cancer and is closely associated with poor prognosis in many …

Cancer is often characterised by the presence of hypoxia and inflammation. Paramount to
the mechanisms controlling cellular responses under such stress stimuli, are the …

Numerous preclinical and clinical studies have demonstrated the significant contribution of
inflammation to the development and progression of various types of cancer. Inflammation in …

Intratumoral cytotoxic CD8+ T cells (CTL) enter a dysfunctional state characterized by
expression of coinhibitory receptors, loss of effector function, and changes in the …

We aim to construct a hypoxia-and immune-associated risk score model to predict the
prognosis of patients with pancreatic ductal adenocarcinoma (PDAC). By unsupervised …

As a strategy to improve the therapeutic success of chimeric antigen receptor T cells (CART)
directed against solid tumors, we here test the combinatorial use of CART and IMSA101, a …