Progress on the pathological tissue microenvironment barrier-modulated nanomedicine

H Han, L Xing, BT Chen, Y Liu, TJ Zhou, Y Wang… - Advanced Drug Delivery …, 2023 - Elsevier
Imbalance in the tissue microenvironment is the main obstacle to drug delivery and
distribution in the human body. Before penetrating the pathological tissue microenvironment …

[HTML][HTML] Extracellular vesicles: emerging roles, biomarkers and therapeutic strategies in fibrotic diseases

J Zhu, S Wang, D Yang, W Xu, H Qian - Journal of Nanobiotechnology, 2023 - Springer
Extracellular vesicles (EVs), a cluster of cell-secreted lipid bilayer nanoscale particles,
universally exist in body fluids, as well as cell and tissue culture supernatants. Over the past …

[HTML][HTML] Engineering organ-on-a-chip to accelerate translational research

J Ko, D Park, S Lee, B Gumuscu, NL Jeon - Micromachines, 2022 - mdpi.com
We guide the use of organ-on-chip technology in tissue engineering applications. Organ-on-
chip technology is a form of microengineered cell culture platform that elaborates the in-vivo …

[HTML][HTML] Micro/nanosystems for controllable drug delivery to the brain

M Tian, Z Ma, GZ Yang - The Innovation, 2024 - ncbi.nlm.nih.gov
Drug delivery to the brain is crucial in the treatment for central nervous system disorders.
While significant progress has been made in recent years, there are still major challenges in …

[HTML][HTML] A microphysiological system-based potency bioassay for the functional quality assessment of mesenchymal stromal cells targeting vasculogenesis

J Lam, B Lee, J Yu, BJ Kwee, Y Kim, J Kim, Y Choi… - Biomaterials, 2022 - Elsevier
Mesenchymal stromal cells (MSCs) continue to be proposed for use in clinical trials to treat
various diseases due to their therapeutic potential to pleiotropically influence endogenous …

Visual/quantitative SERS biosensing chip based on Au-decorated polystyrene sphere microcavity arrays

J Sun, R Wang, L Wang, X Wang, J Wang, Z Shi… - Sensors and Actuators B …, 2023 - Elsevier
A microfluidic chip was designed and fabricated to achieve visual and quantitative sensing
for the biomarker of Epstein-barr virus antibody (EBV IgG) based on TMB chromogenic unit …

[HTML][HTML] Human mini-blood–brain barrier models for biomedical neuroscience research: a review

M Tran, C Heo, LP Lee, H Cho - Biomaterials Research, 2022 - Springer
The human blood–brain barrier (BBB) is a unique multicellular structure that is in critical
demand for fundamental neuroscience studies and therapeutic evaluation. Despite …

[HTML][HTML] From microfluidics to microphysiological systems: Past, present, and future

M Virumbrales-Muñoz, JM Ayuso - Organs-on-a-Chip, 2022 - Elsevier
For over a decade, we have seen significant strides in the microfluidics field that have led to
the concept of microphysiological systems. These systems emerged in the early 2010s as …

Modeling the blood-brain barrier for treatment of central nervous system (CNS) diseases

O Rice, A Surian, Y Chen - Journal of Tissue Engineering, 2022 - journals.sagepub.com
The blood-brain barrier (BBB) is the most specialized biological barrier in the body. This
configuration of specialized cells protects the brain from invasion of molecules and particles …

[HTML][HTML] The recent applications of plga-based nanostructures for ischemic stroke

J Yan, L Huang, J Feng, X Yang - Pharmaceutics, 2023 - mdpi.com
With the accelerated development of nanotechnology in recent years, nanomaterials have
become increasingly prevalent in the medical field. The poly (lactic acid–glycolic acid) …