Cancer-associated fibroblasts (CAFs) are critical components of the tumor microenvironment
(TME) with diverse functions such as extracellular matrix (ECM) remodeling, modulation of …

Transforming growth factor-β (TGF-β) is a cytokine essential for the induction of the fibrotic
response and for the activation of the cancer stroma. Strong evidence suggests that a strong …

Epithelial-mesenchymal transition (EMT) is a cellular process by which epithelial cells lose
their characteristics and acquire mesenchymal traits to promote cell movement. This …

Metastasis is the major cause of cancer-associated death. Partial activation of the epithelial-
to-mesenchymal transition program (partial EMT) was considered a major driver of tumour …

Zinc finger E-box binding homeobox 1 (ZEB1) is a transcription factor that promotes tumor
invasion and metastasis by inducing epithelial-mesenchymal transition (EMT) in carcinoma …

Zinc finger proteins are the largest transcription factor family in human genome. The diverse
combinations and functions of zinc finger motifs make zinc finger proteins versatile in …

Invasion, metastasis and therapy resistance are the major cause of cancer‐associated
deaths, and the EMT‐inducing transcription factor ZEB 1 is a crucial stimulator of these …

Early dissemination, metastasis and therapy resistance are central hallmarks of aggressive
cancer types and the leading cause of cancer-associated deaths. The EMT-inducing …

Pancreatic cancer is the 4th leading cause of cancer deaths in the United States. The
pancreatic cancer phenotype is primarily a consequence of oncogenes disturbing the …

Simple Summary Given the importance of the epithelial-to-mesenchymal transition in tumor
progression and the pivotal role of ZEB1 as a transcriptional repressor during this process …