The issue of heterogeneity of MSC-based advanced therapy medicinal products–a review

AB Česnik, U Švajger - Frontiers in Cell and Developmental Biology, 2024 - frontiersin.org
Mesenchymal stromal stem cells (MSCs) possess a remarkable potential for numerous
clinical applications due to their unique properties including self-renewal …

Translational potential of mesenchymal stem cells in regenerative therapies for human diseases: Challenges and opportunities

S Zhidu, T Ying, J Rui, Z Chao - Stem Cell Research & Therapy, 2024 - Springer
Advances in stem cell technology offer new possibilities for patients with untreated diseases
and disorders. Stem cell-based therapy, which includes multipotent mesenchymal stem cells …

Mesenchymal stem/stromal cells (MSCs): origin, immune regulation, and clinical applications

J Zhou, Y Shi - Cellular & Molecular Immunology, 2023 - nature.com
The associations between inflammation and tissue regeneration are highly conserved
during the evolution of multicellular organisms [1]. Appropriate activation of immune cells is …

Mesenchymal stromal/stem cell tissue source and in vitro expansion impact extracellular vesicle protein and miRNA compositions as well as angiogenic and …

Y Liu, L Sun, Y Li, C Holmes - Journal of Extracellular Vesicles, 2024 - Wiley Online Library
Recently, therapies utilizing extracellular vesicles (EVs) derived from mesenchymal
stromal/stem cells (MSCs) have begun to show promise in clinical trials. However, EV …

Precision nanomedicine with bio-inspired nanosystems: recent trends and challenges in mesenchymal stem cells membrane-coated bioengineered nanocarriers in …

MS Baig, A Ahmad, RR Pathan, RK Mishra - Journal of Xenobiotics, 2024 - mdpi.com
In the recent past, the formulation and development of nanocarriers has been elaborated
into the broader fields and opened various avenues in their preclinical and clinical …

Cell-based Therapies for Acute Respiratory Distress Syndrome: Where Are We Now?

GF Curley, CM O'Kane, DF McAuley… - American Journal of …, 2024 - atsjournals.org
There is considerable interest in the potential for cell-based therapies, particularly
mesenchymal stromal cells (MSCs) and their products, as a therapy for acute respiratory …

Mesenchymal stromal cells restrain the Th17 cell response via L-amino-acid oxidase within lymph nodes

Q Ni, L Zhen, Z Zeng, J Yang, Y Wang, H Xu… - Cell Death & …, 2024 - nature.com
Mesenchymal stromal/stem cells (MSC) have emerged as a promising therapeutic avenue
for treating autoimmune diseases, eliciting considerable interest and discussion regarding …

Unveiling heterogeneity in MSCs: exploring marker-based strategies for defining MSC subpopulations

S Chen, B Liang, J Xu - Journal of Translational Medicine, 2024 - Springer
Mesenchymal stem/stromal cells (MSCs) represent a heterogeneous cell population
distributed throughout various tissues, demonstrating remarkable adaptability to …

Immortalized Canine Adipose-Derived Mesenchymal Stem Cells Maintain the Immunomodulatory Capacity of the Original Primary Cells

Y Yasumura, T Teshima, T Nagashima… - International Journal of …, 2023 - mdpi.com
Mesenchymal stem cells (MSCs) are a promising cell source for stem cell therapy of
intractable diseases in veterinary medicine, but donor-dependent cellular heterogeneity is …

Co-infusion of mesenchymal stromal cells to prevent GVHD after allogeneic hematopoietic cell transplantation from HLA-mismatched unrelated donors after reduced …

G Lombardo, C Lechanteur, A Briquet, L Seidel… - Stem Cell Research & …, 2024 - Springer
Mesenchymal stromal cells (MSC) have immunomodulatory and hematopoiesis-supporting
properties that could potentially benefit hematopoietic stem cell (HSC) engraftment and …