Alcohol dehydrogenases (ADHs) are most known for their roles in oxidation and elimination
of ethanol. Although less known, ADHs also play a critical role in the metabolism of a …

The covalent binding of drugs (metabolites) to proteins to form drug–protein adducts can
have an adverse effect on the body. These adducts are thought to be responsible for …

The drug-metabolizing enzymes that contribute to the metabolism or bioactivation of a drug
play a crucial role in defining the absorption, distribution, metabolism, and excretion …

Drug-specific T cells have been isolated from different patients with allergy. Formation of
hapten–protein complexes, their processing and antigen presentation have been implicated …

The successful choice of hit compounds during drug development programs involves the
integration of structure-activity relationship (SAR) studies with pharmacokinetic …

Soft electrophiles (eg, epoxides, quinones, quinone-imines, quinone-methides, etc.)
generated via the oxidative bioactivation of phenyl, phenolic, amino-, and alkylphenolic …

The bioactivation of drugs is often associated with toxicological outcomes; however, for most
cases, the causal relationship between bioactivation and toxicity is not well established …

Protein covalent adducts formed upon exposure to reactive (mainly electrophilic) chemicals
may lead to the development of a wide range of deleterious health outcomes. Therefore, the …

Data are presented on the formation of potentially toxic metabolites of drugs that are
substrates of human drug metabolizing enzymes. The tabular data lists the formation of …

Antiretroviral therapy has markedly reduced morbidity and mortality for persons living with
human immunodeficiency virus (HIV). Individual tailoring of antiretroviral regimens has the …