AKAP signalling complexes: focal points in space and time
Multiprotein signalling networks create focal points of enzyme activity that disseminate the
intracellular action of many hormones and neurotransmitters. Accordingly, the spatio …
intracellular action of many hormones and neurotransmitters. Accordingly, the spatio …
Localized effects of cAMP mediated by distinct routes of protein kinase A
K Taskén, EM Aandahl - Physiological reviews, 2004 - journals.physiology.org
Taskén, Kjetil, and Einar Martin Aandahl. Localized Effects of cAMP Mediated by Distinct
Routes of Protein Kinase A. Physiol Rev 84: 137–167, 2004; 10.1152/physrev. 00021.2003 …
Routes of Protein Kinase A. Physiol Rev 84: 137–167, 2004; 10.1152/physrev. 00021.2003 …
[HTML][HTML] Regulation of actin-based cell migration by cAMP/PKA
AK Howe - Biochimica et Biophysica Acta (BBA)-Molecular Cell …, 2004 - Elsevier
A wide variety of soluble signaling substances utilize the cyclic AMP-dependent protein
kinase (PKA) pathway to regulate cellular behaviors including intermediary metabolism, ion …
kinase (PKA) pathway to regulate cellular behaviors including intermediary metabolism, ion …
Mechanisms of protein kinase A anchoring
P Skroblin, S Grossmann, G Schäfer… - International review of …, 2010 - Elsevier
The second messenger cyclic adenosine monophosphate (cAMP), which is produced by
adenylyl cyclases following stimulation of G-protein-coupled receptors, exerts its effect …
adenylyl cyclases following stimulation of G-protein-coupled receptors, exerts its effect …
[HTML][HTML] Networking with AKAPs: context-dependent regulation of anchored enzymes
Abstract A-Kinase Anchoring Proteins (AKAPs) orchestrate and synchronize cellular events
by tethering the cAMP-dependent protein kinase (PKA) and other signaling enzymes to …
by tethering the cAMP-dependent protein kinase (PKA) and other signaling enzymes to …
RNA silencing identifies PDE4D5 as the functionally relevant cAMP phosphodiesterase interacting with βarrestin to control the protein kinase A/AKAP79-mediated …
PDE4B and PDE4D provide> 90% of PDE4 cAMP phosphodiesterase activity in human
embryonic kidney (HEK293B2) cells. Their selective small interference RNA (siRNA) …
embryonic kidney (HEK293B2) cells. Their selective small interference RNA (siRNA) …
Minireview: aquaporin 2 trafficking
In the kidney aquaporin-2 (AQP2) provides a target for hormonal regulation of water
transport by vasopressin. Short-term control of water permeability occurs via vesicular …
transport by vasopressin. Short-term control of water permeability occurs via vesicular …
Drugs that regulate local cell signaling: AKAP targeting as a therapeutic option
PJ Bucko, JD Scott - Annual review of pharmacology and …, 2021 - annualreviews.org
Cells respond to environmental cues by mobilizing signal transduction cascades that
engage protein kinases and phosphoprotein phosphatases. Correct organization of these …
engage protein kinases and phosphoprotein phosphatases. Correct organization of these …
A-kinase anchoring proteins: scaffolding proteins in the heart
D Diviani, KL Dodge-Kafka, J Li… - American Journal of …, 2011 - journals.physiology.org
The pleiotropic cyclic nucleotide cAMP is the primary second messenger responsible for
autonomic regulation of cardiac inotropy, chronotropy, and lusitropy. Under conditions of …
autonomic regulation of cardiac inotropy, chronotropy, and lusitropy. Under conditions of …
AKAP-Lbc nucleates a protein kinase D activation scaffold
GK Carnegie, FD Smith, G McConnachie… - Molecular cell, 2004 - cell.com
The transmission of cellular signals often proceeds through multiprotein complexes where
enzymes are positioned in proximity to their upstream activators and downstream substrates …
enzymes are positioned in proximity to their upstream activators and downstream substrates …