Pituitary adenylate cyclase-activating polypeptide (PACAP) is a 38-amino acid C-terminally
α-amidated peptide that was first isolated 20 years ago from an ovine hypothalamic extract …

Melatonin, the major hormone produced by the pineal gland, displays characteristic daily
and seasonal patterns of secretion. These robust and predictable rhythms in circulating …

Pituitary adenylate cyclase-activating polypeptide (PACAP) is a 38-amino acid peptide that
was first isolated from ovine hypothalamic extracts on the basis of its ability to stimulate …

The pineal hormone, melatonin (N-acetyl-5-methoxytryptamine), shows potent receptor-
dependent and-independent actions, which participate in blood pressure regulation. The …

The production of the pineal hormone melatonin is synchronized with day-night cycle via
multisynaptic pathway including suprachiasmatic nucleus linking several physiological …

The melatonin system in preeclamptic pregnancies has been largely overlooked, especially
in the placenta. We have previously documented melatonin production and expression of its …

The pineal gland plays an essential role in vertebrate chronobiology by converting time into
a hormonal signal, melatonin, which is always elevated at night. Here we have analyzed the …

Melatonin is a neurohormone that works as a nighttime signal for circadian integrity and
health maintenance. It is crucial for energy metabolism regulation, and the diabetes effects …

The rat pineal gland has been extensively used in studies of melatonin synthesis. However,
the cellular localization of melatonin synthesis in this species has not been investigated …

In the pineal, melatonin (Mel) is synthesized from serotonin by arylalkylamine-N-
acetyltransferase (AA-NAT) and hydroxyindole-O-methyltransferase (HIOMT). Although it is …