Mutations in genes affecting endocrine signaling, stress responses, metabolism, and
telomeres can all increase the life spans of model organisms. These mutations have …

The human population is increasing at an alarming rate, whereas at the same time
agricultural productivity is decreasing due to the effect of various environmental problems. In …

Disease incidences increase with age, but the molecular characteristics of ageing that lead
to increased disease susceptibility remain inadequately understood. Here we perform a …

Interventions that delay ageing mobilize mechanisms that protect and repair cellular
components,,, but it is unknown how these interventions might slow the functional decline of …

In response to harsh environmental conditions, C. eleganslarvae undergo dauer arrest at
the second molt. The past decade has yielded many insights into the signaling pathways …

Abstract Background In the nematode Caenorhabditis elegans the conserved Ins/IGF-1
signaling pathway regulates many biological processes including life span, stress response …

Epigenetic information undergoes extensive reprogramming in the germline between
generations. This reprogramming may be essential to establish a developmental ground …

In Caenorhabditis elegans, the decision to enter a developmentally arrested dauer larval
stage is triggered by a combination of signals from sensory neurons in response to …

Early studies recognizing the importance of the decapod eyestalk in the endocrine
regulation of crustacean physiology—molting, metabolism, reproduction, osmotic balance …

In Caenorhabditis elegans, the forkhead protein DAF‐16 transduces insulin‐like signals that
regulate larval development and adult lifespan. To identify DAF‐16‐dependent …