[HTML][HTML] Neuroinflammation induces neurodegeneration

D Kempuraj, R Thangavel, PA Natteru… - Journal of neurology …, 2016 - ncbi.nlm.nih.gov
Neurodegenerative diseases such as Alzheimer's disease (AD), Parkinson's disease (PD),
and Multiple Sclerosis (MS) are characterized by neuronal degeneration and neuronal …

Association of COVID-19 with comorbidities: An update

S Chatterjee, LV Nalla, M Sharma… - ACS Pharmacology & …, 2023 - ACS Publications
Coronavirus disease (COVID-19) is caused by severe acute respiratory syndrome-
coronavirus-2 (SARS-CoV-2) which was identified in Wuhan, China in December 2019 and …

Small molecule-driven NLRP3 inflammation inhibition via interplay between ubiquitination and autophagy: implications for Parkinson disease

X Han, S Sun, Y Sun, Q Song, J Zhu, N Song, M Chen… - Autophagy, 2019 - Taylor & Francis
Aging-related, nonresolving inflammation in both the central nervous system (CNS) and
periphery predisposes individuals to the development of neurodegenerative disorders …

Microglial inflammatory-metabolic pathways and their potential therapeutic implication in major depressive disorder

R Rahimian, C Belliveau, R Chen… - Frontiers in psychiatry, 2022 - frontiersin.org
Increasing evidence supports the notion that neuroinflammation plays a critical role in the
etiology of major depressive disorder (MDD), at least in a subset of patients. By virtue of their …

Astrocytic oxidative/nitrosative stress contributes to Parkinson's disease pathogenesis: the dual role of reactive astrocytes

A Rizor, E Pajarillo, J Johnson, M Aschner, E Lee - Antioxidants, 2019 - mdpi.com
Parkinson's disease (PD) is the second most common neurodegenerative disease
worldwide; it is characterized by dopaminergic neurodegeneration in the substantia nigra …

miR-124 and Parkinson's disease: A biomarker with therapeutic potential

E Angelopoulou, YN Paudel, C Piperi - Pharmacological Research, 2019 - Elsevier
Parkinson's disease (PD) is a multifactorial disorder, attributed to a complex interplay
between genetic and epigenetic factors. Although the exact etiology of the disease remains …

MicroRNA-124 regulates the expression of MEKK3 in the inflammatory pathogenesis of Parkinson's disease

L Yao, Y Ye, H Mao, F Lu, X He, G Lu… - Journal of …, 2018 - Springer
Background Parkinson's disease (PD) is the most prevalent neurodegenerative disorder that
is characterised by selective loss of midbrain dopaminergic (DA) neurons. Chronic …

Phytochemicals as inhibitors of tumor necrosis factor alpha and neuroinflammatory responses in neurodegenerative diseases

F Zahedipour, SA Hosseini, NC Henney… - Neural Regeneration …, 2022 - journals.lww.com
Inflammatory processes and proinflammatory cytokines have a key role in the cellular
processes of neurodegenerative diseases and are linked to the pathogenesis of functional …

A lincRNA-p21/miR-181 family feedback loop regulates microglial activation during systemic LPS-and MPTP-induced neuroinflammation

Y Ye, X He, F Lu, H Mao, Z Zhu, L Yao, W Luo… - Cell death & …, 2018 - nature.com
The role of microglial-mediated sustained neuroinflammation in the onset and progression
of Parkinson's disease (PD) is well established, but the mechanisms contributing to …

Mechanism of miR-132-3p promoting neuroinflammation and dopaminergic neurodegeneration in Parkinson's Disease

X Gong, M Huang, L Chen - Eneuro, 2022 - eneuro.org
The major pathology in Parkinson's disease (PD) is neuron injury induced by degeneration
of dopaminergic neurons and the activation of microglial cells. The objective of this study is …