Apical–basal polarity and the control of epithelial form and function
CE Buckley, D St Johnston - Nature reviews Molecular cell biology, 2022 - nature.com
Epithelial cells are the most common cell type in all animals, forming the sheets and tubes
that compose most organs and tissues. Apical–basal polarity is essential for epithelial cell …
that compose most organs and tissues. Apical–basal polarity is essential for epithelial cell …
Cellular signalling by primary cilia in development, organ function and disease
Z Anvarian, K Mykytyn, S Mukhopadhyay… - Nature Reviews …, 2019 - nature.com
Primary cilia project in a single copy from the surface of most vertebrate cell types; they
detect and transmit extracellular cues to regulate diverse cellular processes during …
detect and transmit extracellular cues to regulate diverse cellular processes during …
Genomic regulation of transcription and RNA processing by the multitasking Integrator complex
SA Welsh, A Gardini - Nature Reviews Molecular Cell Biology, 2023 - nature.com
In higher eukaryotes, fine-tuned activation of protein-coding genes and many non-coding
RNAs pivots around the regulated activity of RNA polymerase II (Pol II). The Integrator …
RNAs pivots around the regulated activity of RNA polymerase II (Pol II). The Integrator …
[HTML][HTML] Primary cilia and ciliary signaling pathways in aging and age-related brain disorders
Brain disorders are characterized by the progressive loss of structure and function of the
brain as a consequence of progressive degeneration and/or death of nerve cells. Aging is a …
brain as a consequence of progressive degeneration and/or death of nerve cells. Aging is a …
CCDC15 localizes to the centriole inner scaffold and controls centriole length and integrity
MD Arslanhan, S Cengiz-Emek, E Odabasi… - Journal of Cell …, 2023 - rupress.org
Centrioles are microtubule-based organelles responsible for forming centrosomes and cilia,
which serve as microtubule-organizing, signaling, and motility centers. Biogenesis and …
which serve as microtubule-organizing, signaling, and motility centers. Biogenesis and …
The regulation of cilium assembly and disassembly in development and disease
L Wang, BD Dynlacht - Development, 2018 - journals.biologists.com
The primary cilium is an antenna-like organelle assembled on most types of quiescent and
differentiated mammalian cells. This immotile structure is essential for interpreting …
differentiated mammalian cells. This immotile structure is essential for interpreting …
Hedgehog signal and genetic disorders
N Sasai, M Toriyama, T Kondo - Frontiers in Genetics, 2019 - frontiersin.org
The hedgehog (Hh) family comprises sonic hedgehog (Shh), Indian hedgehog (Ihh), and
desert hedgehog (Dhh), which are versatile signaling molecules involved in a wide …
desert hedgehog (Dhh), which are versatile signaling molecules involved in a wide …
Primary cilia on muscle stem cells are critical to maintain regenerative capacity and are lost during aging
During aging, the regenerative capacity of muscle stem cells (MuSCs) decreases,
diminishing the ability of muscle to repair following injury. We found that the ability of MuSCs …
diminishing the ability of muscle to repair following injury. We found that the ability of MuSCs …
A change of heart: new roles for cilia in cardiac development and disease
L Djenoune, K Berg, M Brueckner… - Nature Reviews Cardiology, 2022 - nature.com
Although cardiac abnormalities have been observed in a growing class of human disorders
caused by defective primary cilia, the function of cilia in the heart remains an underexplored …
caused by defective primary cilia, the function of cilia in the heart remains an underexplored …
Akt-ing up just about everywhere: compartment-specific Akt activation and function in receptor tyrosine kinase signaling
The serine/threonine kinase Akt is a master regulator of many diverse cellular functions,
including survival, growth, metabolism, migration, and differentiation. Receptor tyrosine …
including survival, growth, metabolism, migration, and differentiation. Receptor tyrosine …