Alzheimer's disease (AD) is the most common neurodegenerative disease, which severely
threatens the health of the elderly and causes significant economic and social burdens. The …

Sepsis-associated encephalopathy (SAE) is a collection of clinical syndromes resulting from
sepsis and characterized by widespread brain dysfunction. The high prevalence of SAE has …

Cell lineage specification is accomplished by a concerted action of chromatin remodeling
and tissue-specific transcription factors. However, the mechanisms that induce and maintain …

Epigenetic dysregulation is reported in multiple cancers including Ewing sarcoma (EwS).
However, the epigenetic networks underlying the maintenance of oncogenic signaling and …

Alternative splicing significantly expands biological complexity, particularly in the vertebrate
nervous system. Increasing evidence indicates that developmental and tissue-dependent …

Direct targeting of essential viral enzymes such as proteases, polymerases, and helicases
has long been the major focus of antiviral drug design. Although successful for some viral …

Epigenetic modification of chromatin, including histone methylation and acetylation, plays
critical roles in eukaryotic cells and has a significant impact on chromatin …

The lysine acetyltransferases type 3 (KAT3) family members CBP and p300 are important
transcriptional co-activators, but their specific functions in adult post-mitotic neurons remain …

Abstract Objective Dipeptidyl peptidase IV (DPP4) has been indicated as a possible
prognostic biomarker in papillary thyroid cancer (PTC). However, the mechanism of DPP4 …

Hepcidin (HAMP), an iron regulatory hormone synthesized by liver hepatocytes, works
together with ferritin (FTH) and ferroportin (FPN) in regulating the storage, transport, and …