Contextual determinants of TGFβ action in development, immunity and cancer
CJ David, J Massagué - Nature reviews Molecular cell biology, 2018 - nature.com
Few cell signals match the impact of the transforming growth factor-β (TGFβ) family in
metazoan biology. TGFβ cytokines regulate cell fate decisions during development, tissue …
metazoan biology. TGFβ cytokines regulate cell fate decisions during development, tissue …
Signaling cross talk between TGF-β/Smad and other signaling pathways
K Luo - Cold Spring Harbor perspectives in biology, 2017 - cshperspectives.cshlp.org
Cytokines of the transforming growth factor β (TGF-β) family, including TGF-βs, bone
morphogenic proteins (BMPs), activins, and Nodal, play crucial roles in embryonic …
morphogenic proteins (BMPs), activins, and Nodal, play crucial roles in embryonic …
Defective fatty acid oxidation in renal tubular epithelial cells has a key role in kidney fibrosis development
Renal fibrosis is the histological manifestation of a progressive, usually irreversible process
causing chronic and end-stage kidney disease. We performed genome-wide transcriptome …
causing chronic and end-stage kidney disease. We performed genome-wide transcriptome …
A double take on bivalent promoters
P Voigt, WW Tee, D Reinberg - Genes & development, 2013 - genesdev.cshlp.org
Histone modifications and chromatin-associated protein complexes are crucially involved in
the control of gene expression, supervising cell fate decisions and differentiation. Many …
the control of gene expression, supervising cell fate decisions and differentiation. Many …
Transcriptional control by the SMADs
CS Hill - Cold Spring Harbor perspectives in biology, 2016 - cshperspectives.cshlp.org
The transforming growth factor-β (TGF-β) family of ligands elicit their biological effects by
initiating new programs of gene expression. The best understood signal transducers for …
initiating new programs of gene expression. The best understood signal transducers for …
The TGFbeta superfamily signaling pathway
A Weiss, L Attisano - Wiley Interdisciplinary Reviews …, 2013 - Wiley Online Library
The transforming growth factor (TGF) beta superfamily of secreted factors is comprised of
over 30 members including Activins, Nodals, Bone Morphogenetic Proteins (BMPs), and …
over 30 members including Activins, Nodals, Bone Morphogenetic Proteins (BMPs), and …
[HTML][HTML] Efficient endoderm induction from human pluripotent stem cells by logically directing signals controlling lineage bifurcations
Human pluripotent stem cell (hPSC) differentiation typically yields heterogeneous
populations. Knowledge of signals controlling embryonic lineage bifurcations could …
populations. Knowledge of signals controlling embryonic lineage bifurcations could …
[HTML][HTML] Switch enhancers interpret TGF-β and Hippo signaling to control cell fate in human embryonic stem cells
TA Beyer, A Weiss, Y Khomchuk, K Huang… - Cell reports, 2013 - cell.com
A small toolkit of morphogens is used repeatedly to direct development, raising the question
of how context dictates interpretation of the same cue. One example is the transforming …
of how context dictates interpretation of the same cue. One example is the transforming …
ChIPBase: a database for decoding the transcriptional regulation of long non-coding RNA and microRNA genes from ChIP-Seq data
Long non-coding RNAs (lncRNAs) and microRNAs (miRNAs) represent two classes of
important non-coding RNAs in eukaryotes. Although these non-coding RNAs have been …
important non-coding RNAs in eukaryotes. Although these non-coding RNAs have been …
TGF-β signaling in cell fate control and cancer
Y Yu, XH Feng - Current opinion in cell biology, 2019 - Elsevier
Members of the transforming growth factor-β (TGF-β) family regulate cell fate decisions
during early embryonic development and tissue homeostasis in the adult. Deregulation of …
during early embryonic development and tissue homeostasis in the adult. Deregulation of …