Molecular targets and anticancer activity of quinoline–chalcone hybrids: Literature review

MFA Mohamed, GEDA Abuo-Rahma - RSC advances, 2020 - pubs.rsc.org
α, β-Unsaturated chalcone moieties and quinoline scaffolds play an important role in
medicinal chemistry, especially in the identification and development of potential anticancer …

Chalcones as Versatile Synthons for the Synthesis of 5-and 6-membered Nitrogen Heterocycles

H MT Albuquerque, C MM Santos… - Current Organic …, 2014 - ingentaconnect.com
Chalcones belong to the flavonoid family which constitutes one of the major classes of
naturally occurring oxygen heterocyclic compounds. The α, β-unsaturated carbonyl system …

Synthesis, characterization, theoretical, anti-bacterial and molecular docking studies of quinoline based chalcones as a DNA gyrase inhibitor

MI Abdullah, A Mahmood, M Madni, S Masood… - Bioorganic …, 2014 - Elsevier
A series of fourteen (A 1–A 14) new qunioline based chalcones were synthesized by
condensing 2, 7-dichloro-8-methyl-3-formyl quinoline with acetophenone and …

Chalcones: Versatile intermediates in heterocyclic synthesis

YN Nayak, SL Gaonkar, M Sabu - Journal of Heterocyclic …, 2023 - Wiley Online Library
Chalcones are a fascinating and well‐studied group of organic molecules. Synthesis of
chalcones has been one of the essential areas of organic synthesis over the last few …

One‐pot and two‐pot methods for chalcone derived pyrimidines synthesis and applications

S Farooq, Z Ngaini - Journal of Heterocyclic Chemistry, 2021 - Wiley Online Library
Chalcone‐derived pyrimidine is a well‐known heterocyclic compound that is commonly
present in ribonucleic acid (RNA) and deoxyribonucleic acid (DNA) bio‐isosteres …

Novel pyrazole and imidazolone compounds: synthesis, X-ray crystal structure with theoretical investigation of new pyrazole and imidazolone compounds anticipated …

MA Shalaby, MH BinSabt, SA Rizk, AM Fahim - RSC advances, 2024 - pubs.rsc.org
In this study, we synthesized (2-propoxyphenyl)(3-(p-tolyl) oxiran-2-yl) methanone through
oxidizing the double bond of the respective chalcone via the Weitz–Scheffer epoxidation …

Novel chalcone/aryl carboximidamide hybrids as potent anti-inflammatory via inhibition of prostaglandin E2 and inducible NO synthase activities: design, synthesis …

TS Ibrahim, AH Moustafa, AJ Almalki… - Journal of enzyme …, 2021 - Taylor & Francis
Two series of chalcone/aryl carboximidamide hybrids 4a–f and 6a–f were synthesised and
evaluated for their inhibitory activity against iNOS and PGE2. The most potent derivatives …

Anti-HIV cytotoxicity enzyme inhibition and molecular docking studies of quinoline based chalcones as potential non-nucleoside reverse transcriptase inhibitors …

A Hameed, MI Abdullah, E Ahmed, A Sharif, A Irfan… - Bioorganic …, 2016 - Elsevier
A series of fourteen (A 1–A 14) qunioline based chalcones were screened for reverse
transcriptase inhibitors (RT) and found potentially active against RT. Bioassay, theoretical …

Heterocyclic aspartyl protease inhibitors

Z Zhu, B McKittrick, ZY Sun, CY Yuanzan… - US Patent …, 2010 - Google Patents
First worldwide family litigation filed litigation Critical https://patents. darts-ip. com/? family=
39511364&utm_source= google_patent&utm_medium= platform_link&utm_campaign …

Comparative study on synthesis and biological, pharmaceutical applications of aromatic substituted chalcones

VV Borge, RM Patil - Mini-Reviews in Organic Chemistry, 2023 - ingentaconnect.com
Chalcones (1, 3, diaryl-2-propen-1-ones) are prominent compounds and therefore, various
procedures have been worked out for their synthesis. This review highlights the synthesis …