Over the past 40 years, there has been a strong focus on the development of mathematical
models of angiogenesis, while developmental remodelling has received little such attention …

Elastin is a long-lived extracellular matrix protein that is organized into elastic fibers that
provide elasticity to the arterial wall, allowing stretch and recoil with each cardiac cycle. By …

Medial deterioration leading to thoracic aortic aneurysms arises from multiple causes, chief
among them mutations to the gene that encodes fibrillin-1 and leads to Marfan syndrome …

Abdominal aortic aneurysms (AAAs) are characterized histopathologically by compromised
elastic fiber integrity, lost smooth muscle cells or their function, and remodeled collagen. We …

BACKGROUND: Transmural failure of the aorta is responsible for substantial morbidity and
mortality; it occurs when mechanical stress exceeds strength. The aortic root and ascending …

The evolving microstructure and mechanical properties that promote homeostasis in the
aorta are fundamental to age-specific adaptations and disease progression. We combine ex …

Mature arteries exhibit a preferred biomechanical state in health evidenced by a narrow
range of intramural and wall shear stresses. When stresses are perturbed by changes in …

To assess the contribution of individual TGF-β isoforms to aortopathy in Marfan syndrome
(MFS), we quantified the survival and phenotypes of mice with a combined fibrillin1 (the …

The vagina plays a critical role in supporting the pelvic organs and loss of support leads to
pelvic organ prolapse. It is unknown what microstructural changes influence prolapse …

Microstructural features and mechanical properties are closely related in all soft biological
tissues. Both yet exhibit considerable inter-individual differences and are affected by factors …