Complex physiological processes control whether stem cells self-renew, differentiate or
remain quiescent. Two decades of research have placed the Hippo pathway, a highly …

The Hippo signaling pathway regulates diverse physiological processes, and its dysfunction
has been implicated in an increasing number of human diseases, including cancer. Here …

Nonalcoholic steatohepatitis (NASH) is a leading cause of liver disease worldwide.
However, the molecular basis of how benign steatosis progresses to NASH is incompletely …

Studies of the regenerative capacity of the liver have converged on the Hippo pathway, a
serine/threonine kinase cascade discovered in Drosophila and conserved from unicellular …

Molecular subtypes of small cell lung cancer (SCLC) defined by the expression of key
transcription regulators have recently been proposed in cell lines and limited number of …

The Hippo signaling pathway, also known as the Salvador− Warts− Hippo pathway, is a
regulator of organ size. The pathway takes its name from the Drosophila protein kinase …

Ivermectin is a macrolide antiparasitic drug with a 16-membered ring that is widely used for
the treatment of many parasitic diseases such as river blindness, elephantiasis and scabies …

Background & Aims Primary liver tumors comprise distinct subtypes. A subset of intrahepatic
cholangiocarcinoma (iCCA) can arise from cell fate reprogramming of mature hepatocytes in …

Yes-Associated Protein (YAP) and Transcriptional Co-activator with PDZ-binding Motif (TAZ)
have both emerged as important drivers of cancer progression and metastasis. YAP and …

The Hippo pathway is a central regulator of organ size and tissue homeostasis. Hippo
kinases and adaptor proteins mediate the phosphorylation and inactivation of YAP and TAZ …