Zebrafish as an alternative animal model in human and animal vaccination research
RL Bailone, HCS Fukushima… - Laboratory animal …, 2020 - Springer
Much of medical research relies on animal models to deepen knowledge of the causes of
animal and human diseases, as well as to enable the development of innovative therapies …
animal and human diseases, as well as to enable the development of innovative therapies …
Modelling viral infections using zebrafish: innate immune response and antiviral research
Zebrafish possess a highly developed immune system that is remarkably similar to the
human one. Therefore, it is expected that the majority of the signalling pathways and …
human one. Therefore, it is expected that the majority of the signalling pathways and …
A robust human norovirus replication model in zebrafish larvae
J Van Dycke, A Ny, N Conceição-Neto, J Maes… - PLoS …, 2019 - journals.plos.org
Human noroviruses (HuNoVs) are the most common cause of foodborne illness, with a
societal cost of $60 billion and 219,000 deaths/year. The lack of robust small animal models …
societal cost of $60 billion and 219,000 deaths/year. The lack of robust small animal models …
Zebrafish models of human disease: gaining insight into human disease at ZFIN
YM Bradford, S Toro, S Ramachandran, L Ruzicka… - ILAR …, 2017 - academic.oup.com
Abstract The Zebrafish Model Organism Database (ZFIN; https://zfin. org) is the central
resource for genetic, genomic, and phenotypic data for zebrafish (Danio rerio) research …
resource for genetic, genomic, and phenotypic data for zebrafish (Danio rerio) research …
The Macrophage-Specific Promoter mfap4 Allows Live, Long-Term Analysis of Macrophage Behavior during Mycobacterial Infection in Zebrafish
Transgenic labeling of innate immune cell lineages within the larval zebrafish allows for real-
time, in vivo analyses of microbial pathogenesis within a vertebrate host. To date, labeling of …
time, in vivo analyses of microbial pathogenesis within a vertebrate host. To date, labeling of …
Intranasal delivery of SARS-CoV-2 spike protein is sufficient to cause olfactory damage, inflammation and olfactory dysfunction in zebrafish
Anosmia, loss of smell, is a prevalent symptom of SARS-CoV-2 infection. Anosmia may be
explained by several mechanisms driven by infection of non-neuronal cells and damage in …
explained by several mechanisms driven by infection of non-neuronal cells and damage in …
Infection of zebrafish larvae with human norovirus and evaluation of the in vivo efficacy of small-molecule inhibitors
We have recently established that human norovirus (HuNoV) replicates efficiently in
zebrafish larvae after inoculation of a clinical sample into the yolk, providing a simple and …
zebrafish larvae after inoculation of a clinical sample into the yolk, providing a simple and …
Replication-competent influenza A viruses expressing reporter genes
Influenza A viruses (IAV) cause annual seasonal human respiratory disease epidemics. In
addition, IAV have been implicated in occasional pandemics with inordinate health and …
addition, IAV have been implicated in occasional pandemics with inordinate health and …
Teleost swim bladder, an ancient air-filled organ that elicits mucosal immune responses
The air-filled organs (AOs) of vertebrates (lungs and swim bladders) have evolved unique
functions (air-breathing or buoyancy control in water) to adapt to different environments …
functions (air-breathing or buoyancy control in water) to adapt to different environments …
Using the ferret as an animal model for investigating influenza antiviral effectiveness
The concern of the emergence of a pandemic influenza virus has sparked an increased
effort toward the development and testing of novel influenza antivirals. Central to this is the …
effort toward the development and testing of novel influenza antivirals. Central to this is the …