Two of the most fascinating bacterial nanomachines—the broadly disseminated rotary
flagellum at the heart of cellular motility and the eukaryotic cell–puncturing injectisome …

Recent studies applying advanced imaging techniques are changing the way we
understand bacterial cell surfaces, bringing new knowledge on everything from single-cell …

β-Barrel outer membrane proteins (OMPs) represent the major proteinaceous component of
the outer membrane (OM) of Gram-negative bacteria. These proteins perform key roles in …

Abstract Bacteriophage (“bacteria eaters”) or phage is the collective term for viruses that
infect bacteria. While most phages are pathogens that kill their bacterial hosts, the …

The type III secretion (T3S) injectisome is a specialized protein nanomachine that is critical
for the pathogenicity of many Gram-negative bacteria, including purveyors of plague, typhoid …

Bacterial lipoproteins are lipid-anchored proteins that contain acyl groups covalently
attached to the N-terminal cysteine residue of the mature protein. Lipoproteins are …

The type II secretion system (T2SS) delivers toxins and a range of hydrolytic enzymes,
including proteases, lipases, and carbohydrate-active enzymes, to the cell surface or …

The β-barrel assembly machinery (BAM) complex is essential for localization of surface
proteins on bacterial cells, but the mechanism by which it functions is unclear. We …

The t ranslocation and a ssembly m odule (TAM) has been proposed to play a crucial role in
the assembly of a small subset of outer membrane proteins (OMPs) in Proteobacteria based …

Increasing antibacterial resistance presents a major challenge in antibiotic discovery. One
attractive target in Gram-negative bacteria is the unique asymmetric outer membrane (OM) …