[HTML][HTML] Possibilities and challenges for developing a successful vaccine for leishmaniasis
Leishmaniasis is a vector-borne disease caused by different species of protozoan parasites
of the genus Leishmania. It is a major health problem yet neglected tropical diseases, with …
of the genus Leishmania. It is a major health problem yet neglected tropical diseases, with …
[HTML][HTML] What's behind a sand fly bite? The profound effect of sand fly saliva on host hemostasis, inflammation and immunity
M Abdeladhim, S Kamhawi, JG Valenzuela - Infection, Genetics and …, 2014 - Elsevier
Sand flies are blood-feeding insects and vectors of the Leishmania parasite. For many
years, saliva of these insects has represented a gold mine for the discovery of molecules …
years, saliva of these insects has represented a gold mine for the discovery of molecules …
[HTML][HTML] Vaccination in leishmaniasis: a review article
L Abdellahi, F Iraji, A Mahmoudabadi… - Iranian Biomedical …, 2022 - ncbi.nlm.nih.gov
Leishmaniasis is caused by protozoan Leishmania parasites that are transmitted through
female sandfly bites. The disease is predominantly endemic to the tropics and semi-tropics …
female sandfly bites. The disease is predominantly endemic to the tropics and semi-tropics …
[HTML][HTML] Leishmania tarentolae: a vaccine platform to target dendritic cells and a surrogate pathogen for next generation vaccine research in leishmaniases and viral …
Parasites of the genus Leishmania are unusual unicellular microorganisms in that they are
characterized by the capability to subvert in their favor the immune response of mammalian …
characterized by the capability to subvert in their favor the immune response of mammalian …
A sand fly salivary protein vaccine shows efficacy against vector-transmitted cutaneous leishmaniasis in nonhuman primates
F Oliveira, E Rowton, H Aslan, R Gomes… - Science translational …, 2015 - science.org
Currently, there are no commercially available human vaccines against leishmaniasis. In
rodents, cellular immunity to salivary proteins of sand fly vectors is associated to protection …
rodents, cellular immunity to salivary proteins of sand fly vectors is associated to protection …
Vaccine candidates against leishmania under current research
Introduction: The search for vaccines to prevent human leishmaniasis is an active field of
investigation aimed to prevent the devastating effects of this family of diseases on human …
investigation aimed to prevent the devastating effects of this family of diseases on human …
Leishmaniasis and various immunotherapeutic approaches
Leishmaniasis is a vector-borne infectious disease caused by multiple Leishmania (L.)
species with diverse clinical manifestations. There is currently no vaccine against any form …
species with diverse clinical manifestations. There is currently no vaccine against any form …
Mosquito saliva: the hope for a universal arbovirus vaccine?
JE Manning, DM Morens, S Kamhawi… - The Journal of …, 2018 - academic.oup.com
Arthropod-borne viruses (arboviruses) are taxonomically diverse causes of significant
morbidity and mortality. In recent decades, important mosquito-borne viruses such as West …
morbidity and mortality. In recent decades, important mosquito-borne viruses such as West …
Leishmania vaccine development: exploiting the host–vector–parasite interface
SG Reed, RN Coler, D Mondal, S Kamhawi… - Expert review of …, 2016 - Taylor & Francis
Visceral leishmaniasis (VL) is a disease transmitted by phlebotomine sand flies, fatal if
untreated, and with no available human vaccine. In rodents, cellular immunity to Leishmania …
untreated, and with no available human vaccine. In rodents, cellular immunity to Leishmania …
[HTML][HTML] Pre-clinical antigenicity studies of an innovative multivalent vaccine for human visceral leishmaniasis
P Cecilio, B Pérez-Cabezas, L Fernández… - PLoS Neglected …, 2017 - journals.plos.org
The notion that previous infection by Leishmania spp. in endemic areas leads to robust anti-
Leishmania immunity, supports vaccination as a potentially effective approach to prevent …
Leishmania immunity, supports vaccination as a potentially effective approach to prevent …