Phage therapy: what have we learned?

A Górski, R Międzybrodzki, M Łobocka… - Viruses, 2018 - mdpi.com
In this article we explain how current events in the field of phage therapy may positively
influence its future development. We discuss the shift in position of the authorities …

[HTML][HTML] Harnessing the metabolic potential of Streptococcus thermophilus for new biotechnological applications

S Markakiou, P Gaspar, E Johansen, AA Zeidan… - Current opinion in …, 2020 - Elsevier
Highlights•Streptococcus thermophilus is superbly adapted to the dairy environment.•Sugar
metabolism, proteolysis and protocooperation are key properties of strains.•Genome editing …

Illuminating the oral microbiome and its host interactions: tools and approaches for molecular microbiology studies

J Merritt, J Kreth - FEMS Microbiology Reviews, 2023 - academic.oup.com
Advancements in DNA sequencing technologies within the last decade have stimulated an
unprecedented interest in the human microbiome, largely due the broad diversity of human …

Genome editing in Streptococcus mutans through self‐targeting CRISPR arrays

T Gong, B Tang, X Zhou, J Zeng, M Lu… - Molecular Oral …, 2018 - Wiley Online Library
Streptococcus mutans is the primary etiological agent of human dental caries. Its major
virulence factors, glucosyltransferases (Gtfs), utilize sucrose to synthesize extracellular …

Advances in Genetic Tools and Their Application in Streptococcus thermophilus

R Zhao, Z Chen, J Liang, J Dou, F Guo, Z Xu, T Wang - Foods, 2023 - mdpi.com
Streptococcus thermophilus is a traditional starter. Nowadays, key aspects of S.
thermophilus physiology have been revealed concerning the phenotypic traits relevant for …

Metabolic modeling of Streptococcus mutans reveals complex nutrient requirements of an oral pathogen

K Jijakli, PA Jensen - Msystems, 2019 - Am Soc Microbiol
Streptococcus mutans is a Gram-positive bacterium that thrives under acidic conditions and
is a primary cause of tooth decay (dental caries). To better understand the metabolism of S …

A short protocol for gene knockout and complementation in Xylella fastidiosa shows that one of the type IV pilin paralogs (PD1926) is needed for twitching while …

PP Kandel, H Chen, L De La Fuente - Applied and environmental …, 2018 - Am Soc Microbiol
Twitching motility is one of the major virulence factors of the plant-pathogenic bacterium
Xylella fastidiosa, and it is mediated by type IV pili (TFP) that are present at one of the cell …

Identification of Streptococcus mutans genes involved in fluoride resistance by screening of a transposon mutant library

J Yu, Y Wang, D Han, W Cao, L Zheng… - Molecular Oral …, 2020 - Wiley Online Library
Fluoride has been used as an effective anticaries agent for more than 70 years, which might
result in the emergence of fluoride‐resistant strains. However, the fluoride resistance …

Plasmalogen, a glycerophospholipid crucial for Streptococcus mutans acid tolerance and colonization

R Mu, S Momeni, M Krieger, B Xie, X Cao… - Applied and …, 2024 - Am Soc Microbiol
Plasmalogen is a specific glycerophospholipid present in both animal and bacterial
organisms. It plays a crucial function in eukaryotic cellular processes and is closely related …

Disruption of the adh (Acetoin Dehydrogenase) Operon Has Wide-Ranging Effects on Streptococcus mutans Growth and Stress Response

P Zuber, MM Nakano, JK Kajfasz… - Journal of …, 2022 - Am Soc Microbiol
The agent largely responsible for initiating dental caries, Streptococcus mutans, produces
acetoin dehydrogenase that is encoded by the adh operon. The operon consists of the adhA …