Cancer has been a leading cause of death for decades. This dismal statistic has increased
efforts to prevent the disease or to detect it early, when treatment is less invasive, relatively …

The haematopoietic stem cell (HSC) microenvironment in the bone marrow, termed the
niche, ensures haematopoietic homeostasis by controlling the proliferation, self-renewal …

Age-related change in human haematopoiesis causes reduced regenerative capacity,
cytopenias, immune dysfunction and increased risk of blood cancer,–, but the reason for …

Understanding the genetic and nongenetic determinants of tumor protein 53 (TP53)-
mutation-driven clonal evolution and subsequent transformation is a crucial step toward the …

Hematopoietic stem cells (HSCs) mediate regeneration of the hematopoietic system
following injury, such as following infection or inflammation. These challenges impair HSC …

Inflammation is an evolutionarily selected defense response to infection or tissue damage
that involves activation and consumption of immune cells in order to reestablish and …

The activation of mostly quiescent haematopoietic stem cells (HSCs) is a prerequisite for life-
long production of blood cells. This process requires major molecular adaptations to allow …

A major obstacle in the treatment of acute myeloid leukemia (AML) is refractory disease or
relapse after achieving remission. The latter arises from a few therapy-resistant cells within …

Trained innate immunity fosters a sustained favorable response of myeloid cells to a
secondary challenge, despite their short lifespan in circulation. We thus hypothesized that …

Stem cell niches are specialized microenvironments that promote the maintenance of stem
cells and regulate their function. Recent advances have improved our understanding of the …